IBB-Institute for Biotechnology and Bioengineering, Centre for Biological Engineering, Universidade do Minho, Campus de Gualtar, 4710-057, Braga, Portugal.
Eur J Clin Microbiol Infect Dis. 2012 Nov;31(11):2905-10. doi: 10.1007/s10096-012-1675-x. Epub 2012 Jun 20.
Infective endocarditis despite advances in diagnosis remains a common cause of hospitalization, with high morbidity and mortality rates. Through literature review it is possible to conclude that polymicrobial endocarditis occurs mainly in intravenous drug abusers with predominance in the right side of the heart, often with tricuspid valve involvement. This fact can be associated with the type of drug used by the patients; therefore, knowledge of the patient's history is critical for adjustment of the therapy. It is also important to emphasize that the most common combinations of organisms in polymicrobial infective endocarditis are: Staphylococcus aureus, Streptococcus pneumonia and Pseudomonas aeruginosa, as well as mixed cultures of Candida spp. and bacteria. A better understanding of the epidemiology and associated risk factors are required in order to develop an efficient therapy, although PE studies are difficult to perform due to the rarity of cases and lack of prospective cohorts.
尽管在诊断方面取得了进展，但感染性心内膜炎仍然是住院治疗的常见原因，其发病率和死亡率都很高。通过文献回顾，可以得出结论，多微生物性心内膜炎主要发生在静脉药物滥用者中，以心脏右侧为主，常伴有三尖瓣受累。这一事实可能与患者使用的药物类型有关；因此，了解患者的病史对于调整治疗至关重要。还需要强调的是，多微生物感染性心内膜炎中最常见的病原体组合是：金黄色葡萄球菌、肺炎链球菌和铜绿假单胞菌，以及念珠菌和细菌的混合培养物。为了制定有效的治疗方案，需要更好地了解流行病学和相关危险因素，尽管由于病例罕见和缺乏前瞻性队列，PE 研究难以进行。
