Center of Educational Technology, The Fourth Military Medical University, 169 Changlexi Road, Xi'an 710032, Shannxi, People's Republic of China.
Mol Biol Rep. 2012 Aug;39(8):8457-63. doi: 10.1007/s11033-012-1699-4. Epub 2012 Jun 20.
A number of case-control studies were conducted to investigate the association of IL6 gene polymorphisms with colorectal cancer (CRC). However, the results were not always consistent. We performed a systematic review and meta-analysis to examine the association between the IL6 gene polymorphisms and CRC. Data were collected from the following electronic databases: PubMed, EMBASE, Web of Science, BIOSIS Previews, HuGENet, and Chinese Biomedical Literature Database, with the last report up to July 2011. A total of 17 studies involving 4 SNPs were included (16 for rs1800795, 2 for rs1800796, 2 for rs1800797, and 1 for rs13306435). Overall, no significant association of these polymorphisms with CRC was found in heterozygote comparisons as well as homozygote comparison, dominant genetic model and recessive model. In subgroup analysis, among studies using population-based controls, fulfilling Hardy-Weinberg equilibrium, or using Taqman genotyping method, we did not find any significant association. However, the rs1800795 C allele was significantly associated with reduced risk for CRC among persons who regularly or currently took NSAIDs (four studies, OR = 0.750; 95 % CI, 0.64-0.88; P = 0.474 for heterogeneity test), and with increased risk for CRC among persons who drank (one study, OR = 1.97; 95 % CI, 1.32-2.94). Individuals with the rs1800795 C allele in the IL6 gene have a significantly lower risk of CRC, but in the setting of NSAIDs use. Further studies are merited to assess the association between the IL6 gene polymorphisms and CRC risk among persons who take NSAIDs, drink or smoke, etc.
一些病例对照研究调查了白细胞介素 6（IL6）基因多态性与结直肠癌（CRC）的相关性。然而，结果并不总是一致的。我们进行了系统评价和荟萃分析，以检验 IL6 基因多态性与 CRC 之间的相关性。数据来自以下电子数据库：PubMed、EMBASE、Web of Science、BIOSIS Previews、HuGENet 和中国生物医学文献数据库，检索时间截至 2011 年 7 月。共纳入 17 项研究，涉及 4 个 SNP（rs1800795 有 16 项，rs1800796 有 2 项，rs1800797 有 2 项，rs13306435 有 1 项）。总体而言，在杂合子比较、纯合子比较、显性遗传模型和隐性遗传模型中，这些多态性与 CRC 无显著相关性。在亚组分析中，在使用基于人群的对照、符合 Hardy-Weinberg 平衡或使用 Taqman 基因分型方法的研究中，我们没有发现任何显著关联。然而，rs1800795 的 C 等位基因与经常或目前服用非甾体抗炎药（NSAIDs）的人群中 CRC 风险降低显著相关（四项研究，OR=0.750；95%CI，0.64-0.88；P=0.474 用于异质性检验），与饮酒人群中 CRC 风险增加显著相关（一项研究，OR=1.97；95%CI，1.32-2.94）。IL6 基因中 rs1800795 的 C 等位基因个体患 CRC 的风险显著降低，但在 NSAIDs 使用的情况下。需要进一步的研究来评估 IL6 基因多态性与服用 NSAIDs、饮酒或吸烟等人群中 CRC 风险之间的关系。
