Faculty of Physical Education, Jozef Pilsudski University of Physical Education in Warsaw, 00-809 Warsaw, Poland.
Military Institute of Hygiene and Epidemiology, 01-163 Warsaw, Poland.
Genes (Basel). 2021 Sep 25;12(10):1498. doi: 10.3390/genes12101498.
Interleukin 6 (IL-6) is a cytokine with both pro- and anti-inflammatory actions, but is also considered as a "metabolic hormone" involved in immune responses, affecting glucose, protein and lipid metabolism. It has been proposed to be related to obesity, but various results have been presented. Thus, in this study, the very homogenous population of young, male military professionals, living in the same conditions involving high physical activity, has been selected to avoid the influence of environmental factors. The subjects were divided into groups depending on the obesity parameters BMI (body mass index) and fat percentage (fat%), and the following SNPs (Single Nucleotide Polymorphisms) were analyzed: rs1800795, rs1800796 and rs13306435. No relation was found between obesity parameters and polymorphisms rs1800795, rs1800796 and rs13306435. It may be postulated that even if a genetic predisposition involves genes, this effect in individuals with obesity of a low grade is minor, or can be avoided or at least markedly reduced by changes in lifestyle.
白细胞介素 6（IL-6）是一种具有促炎和抗炎作用的细胞因子，但也被认为是一种“代谢激素”，参与免疫反应，影响葡萄糖、蛋白质和脂质代谢。它与肥胖有关，但各种结果不一。因此，在这项研究中，选择了非常同质的年轻男性军事专业人员群体，他们生活在涉及高体力活动的相同条件下，以避免环境因素的影响。研究对象根据肥胖参数 BMI（体重指数）和脂肪百分比（脂肪%）进行分组，并分析了以下 SNPs（单核苷酸多态性）：rs1800795、rs1800796 和 rs13306435。肥胖参数与 SNPs rs1800795、rs1800796 和 rs13306435 之间没有关系。可以假设，即使遗传易感性涉及基因，但在肥胖程度较低的个体中，这种影响很小，或者可以通过生活方式的改变来避免或至少显著减少。
