Department of Community Health, Institute of Health and Society, University of Oslo, Oslo, Norway.
Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Br J Nutr. 2013 Feb 14;109(3):529-38. doi: 10.1017/S000711451200133X. Epub 2012 May 4.
The objective of the present study was to explore whether a culturally adapted lifestyle education programme would improve the risk factor profile for type 2 diabetes (T2D) and the metabolic syndrome (MetS) among Pakistani immigrant women in Oslo, Norway. The randomised controlled trial (the InnvaDiab study), lasting 7 ± 1 months, comprised six educational sessions about blood glucose, physical activity and diet. Participants (age 25-62 years) were randomised into either a control (n 97) or an intervention (n 101) group. Primary outcome variables were fasting and 2 h blood glucose, and secondary outcome variables were fasting levels of insulin, C-peptide, lipids, glycated Hb, BMI, waist circumference and blood pressure, measured 1-3 weeks before and after the intervention. During the intervention period, the mean fasting blood glucose decreased by 0·16 (95 % CI -0·27, -0·05) mmol/l in the intervention group, and remained unchanged in the control group (difference between the groups, P=0·022). Glucose concentration 2 h after the oral glucose tolerance test decreased by 0·53 (95 % CI -0·84, -0·21) mmol/l in the intervention group, but not significantly more than in the control group. A larger reduction in fasting insulin was observed in the intervention group than in the control group (between-group difference, P= 0·036). Among the individuals who attended four or more of the educational sessions (n 59), we found a more pronounced decrease in serum TAG (-0·1 (95 % CI -0·24, 0·07) mmol/l) and BMI (-0·48 (95 % CI -0·78, -0·18) kg/m²) compared with the control group. During the intervention period, there was a significant increase in participants having the MetS in the control group (from 41 to 57 %), which was not seen in the intervention group (from 44 to 42 %). Participation in a culturally adapted education programme may improve risk factors for T2D and prevent the development of the MetS in Pakistani immigrant women.
本研究旨在探讨文化适应生活方式教育方案是否能改善挪威奥斯陆巴基斯坦裔移民女性的 2 型糖尿病（T2D）和代谢综合征（MetS）的风险因素谱。这项随机对照试验（InnvaDiab 研究）持续 7±1 个月，包含 6 次关于血糖、身体活动和饮食的教育课程。参与者（年龄 25-62 岁）被随机分为对照组（n97）或干预组（n101）。主要结局变量为空腹和 2 h 血糖，次要结局变量为空腹胰岛素、C 肽、血脂、糖化血红蛋白、BMI、腰围和血压，在干预前 1-3 周和干预后进行测量。在干预期间，干预组的空腹血糖平均降低了 0.16（95%CI-0.27，-0.05）mmol/L，而对照组则保持不变（组间差异，P=0.022）。口服葡萄糖耐量试验后 2 h 血糖浓度降低了 0.53（95%CI-0.84，-0.21）mmol/L，但与对照组相比无显著差异。干预组空腹胰岛素的降低幅度大于对照组（组间差异，P=0.036）。在参加了 4 次或更多教育课程的个体（n59）中，我们发现血清 TAG（-0.1（95%CI-0.24，0.07）mmol/L）和 BMI（-0.48（95%CI-0.78，-0.18）kg/m²）的降低更为明显与对照组相比。在干预期间，对照组中患有 MetS 的人数显著增加（从 41 人增加到 57%），而干预组则没有（从 44 人增加到 42%）。参与文化适应教育方案可能会改善 T2D 的风险因素，并预防巴基斯坦裔移民女性代谢综合征的发生。
