高龄男性慢性阻塞性肺疾病与认知功能衰退的关联
Association of chronic obstructive pulmonary disease with cognitive decline in very elderly men.
作者信息
Zhou Guoqing, Liu Jinxia, Sun Fang, Xin Xiaofeng, Duan Lihui, Zhu Xiaowei, Shi Zhaorong
机构信息
Department of Geriatric Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.
出版信息
Dement Geriatr Cogn Dis Extra. 2012 Jan;2(1):219-28. doi: 10.1159/000338378. Epub 2012 May 22.
AIM
To determine the change in cognitive function in very elderly men with chronic obstructive pulmonary disease (COPD) over a 3-year period relative to age-and education-matched controls.
METHODS
In this hospital-based, prospective case-control study, we evaluated a consecutive series of 110 very elderly men with COPD and 110 control subjects who were hospitalized between January and December 2007. All the subjects performed cognitive tests at baseline and underwent annual evaluations (for 3 years), which included the Mini-Mental State Examination, word list recall, delayed recall, animal category fluency, and the symbol digit modalities test.
RESULTS
In mixed-effects models adjusted for hypertension and coronary heart disease, COPD was associated with a more rapid rate of cognitive decline based on the Mini-Mental State Examination, word list recall, delayed recall, animal category fluency, and the symbol digit modalities test (all p < 0.01) compared to controls.
CONCLUSION
COPD is associated with a more rapid rate of cognitive decline in very elderly persons.
目的
确定患有慢性阻塞性肺疾病（COPD）的高龄男性在3年期间相对于年龄和教育程度匹配的对照组认知功能的变化。
方法
在这项基于医院的前瞻性病例对照研究中，我们评估了2007年1月至12月期间连续收治的110例患有COPD的高龄男性和110例对照受试者。所有受试者在基线时进行认知测试，并接受年度评估（为期3年），评估内容包括简易精神状态检查表、单词列表回忆、延迟回忆、动物类别流畅性以及符号数字模式测试。
结果
在针对高血压和冠心病进行调整的混合效应模型中，与对照组相比，基于简易精神状态检查表、单词列表回忆、延迟回忆、动物类别流畅性以及符号数字模式测试，COPD与认知功能下降速度更快相关（所有p<0.01）。
结论
COPD与高龄人群认知功能下降速度更快相关。
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