Laboratório de Desenvolvimento e Ensaio de Medicamentos, Universidade Estadual da Paraíba, 58.429-500 Campina Grande, PB, Brazil.
Evid Based Complement Alternat Med. 2012;2012:681207. doi: 10.1155/2012/681207. Epub 2012 Jun 6.
Dental pathologies can be caused by plaque-forming bacteria and yeast, which reside in the oral cavity. The bacteria growing in dental plaque, a naturally occurring biofilm, display increased resistance to antimicrobial agents. The objective was the evaluation of a preclinical assay of medicinal plants of the semiarid region from the northeast against oral pathogenic microorganism, aiming at bioprospecting a new product. The selection of plant material for this study was based on the ethnobotanical data on the traditional use of plants from the semiarid region. The thirty extracts were subjected to the determination of antibiofilm activity against gram-positive, gram-negative bacteria and yeast. The hydroalcoholic extract which showed positive antibiofilm activity against most of the microorganisms tested in agar diffusion assay was further tested for the determination of minimum inhibitory concentration (MIC) and Bioassay with Artemia salina. Plant samples tested in this study exhibited good antibiofilm activity for the treatment of oral problems. The Schinopsis brasiliensis showed greater activity for Pseudomonas aeruginosa and Staphylococcus aureus, but toxicity against Artemia salina.
口腔病理可由口腔内存在的形成菌斑的细菌和酵母引起。在牙菌斑中生长的细菌，一种自然存在的生物膜，显示出对抗微生物药物的增加的抵抗力。目的是评估来自东北部半干旱地区的药用植物对口腔致病微生物的临床前检测，旨在寻找新的产品。本研究中植物材料的选择基于对半干旱地区植物传统用途的民族植物学数据。对 30 种提取物进行了抗革兰氏阳性、革兰氏阴性细菌和酵母生物膜活性的测定。在琼脂扩散试验中对大多数测试微生物表现出阳性抗生物膜活性的水醇提取物，进一步进行了最小抑菌浓度（MIC）测定和卤虫生物测定。在这项研究中测试的植物样本对治疗口腔问题显示出良好的抗生物膜活性。Schinopsis brasiliensis 对铜绿假单胞菌和金黄色葡萄球菌表现出更强的活性，但对卤虫有毒性。
