Endocrinology and Metabolism Department, Peking University People's Hospital, Beijing, China.
PLoS One. 2012;7(6):e38962. doi: 10.1371/journal.pone.0038962. Epub 2012 Jun 18.
To investigate the daily insulin doses and the ratio of basal insulin to total daily insulin in Chinese type 2 diabetic patients who received basal bolus insulin therapy.
METHODOLOGY/PRINCIPAL FINDINGS: Totally 2480 patients prescribed with pre-meal bolus insulin and bedtime basal insulin were included. The mean daily insulin doses was 38.22 ± 14.92 IU/day, the mean daily insulin doses per weight was 0.58 ± 0.22 IU/kg, the mean bolus insulin dose was 0.44 ± 0.17 IU/kg and the mean basal insulin dose was 0.13 ± 0.08 IU/kg. The mean basal/total daily insulin ratio (BD/TDD) was 0.23 ± 0.08. In most patients (47.94%), the BD/TDD was between 0.20 and 0.30. Diabetic duration, BMI, HbA1c, fasting and postprandial blood glucose level were positively associated with daily insulin dose, while age was negatively associated with daily insulin dose. Diabetic duration, BMI, HbA1c, fasting blood glucose level, and using metformin were positively associated with BD/TDD ratio, while age, postprandial C peptide, postprandial blood glucose level and CRE level were negatively associated with BD/TDD ratio.
CONCLUSIONS/SIGNIFICANCE: The daily insulin doses of intensive treatment in Chinese type 2 diabetic patients was 38.22 IU/day, the mean daily insulin doses per weight was 0.58 IU/kg, mean BD/TDD ratio was 0.23.
研究接受基础-餐时胰岛素方案治疗的中国 2 型糖尿病患者的每日胰岛素剂量和基础胰岛素与每日总胰岛素剂量的比例。
方法/主要发现：共纳入 2480 例接受餐前餐时胰岛素和睡前基础胰岛素治疗的患者。平均每日胰岛素剂量为 38.22±14.92IU/天，平均每公斤体重的胰岛素剂量为 0.58±0.22IU/kg，平均餐时胰岛素剂量为 0.44±0.17IU/kg，平均基础胰岛素剂量为 0.13±0.08IU/kg。基础胰岛素与每日总胰岛素剂量的比例（BD/TDD）的平均值为 0.23±0.08。在大多数患者（47.94%）中，BD/TDD 处于 0.20 至 0.30 之间。糖尿病病程、BMI、HbA1c、空腹和餐后血糖水平与胰岛素剂量呈正相关，而年龄与胰岛素剂量呈负相关。糖尿病病程、BMI、HbA1c、空腹血糖水平和使用二甲双胍与 BD/TDD 比值呈正相关，而年龄、餐后 C 肽、餐后血糖水平和 CRE 水平与 BD/TDD 比值呈负相关。
结论/意义：中国 2 型糖尿病患者强化治疗的每日胰岛素剂量为 38.22IU/天，平均每公斤体重的胰岛素剂量为 0.58IU/kg，平均 BD/TDD 比值为 0.23。
