在同一受试者中测量的内皮依赖性血流介导的血管舒张的季节性变化。
Seasonal variation of endothelium-dependent flow-mediated vasodilation measured in the same subjects.
作者信息
Iwata Masako, Miyashita Yutaka, Kumagai Hiromichi
出版信息
Am J Cardiovasc Dis. 2012;2(2):111-5. Epub 2012 May 15.
BACKGROUND
Seasonal variation of flow-mediated vasodilation (FMD) remains controversial. A large cohort study showing that FMD was highest in summer and lowest in winter has been performed in a cross-sectional manner on different populations in different seasons, and the results for the same population were not compared.
METHODS
FMD was compared between the cool season (14.4 ± 4.4°C) and warm season (28.8 ± 1.0°C) in the same 27 outpatients with hypertension, diabetes mellitus and/or hyperlipidemia.
RESULTS
The mean resting brachial artery diameter was significantly larger in the warm season than in the cool season. The maximal post-deflation brachial artery diameter was also significantly larger in the warm season than in the cool season. FMD, which was calculated from the resting diameter and the maximal diameter, was significantly higher in the warm season than in the cool season even when expressed as the relative value (4.74 ± 2.15 vs. 5.71 ± 2.17%, p=0.03) or absolute value (0.18 ± 0.08 vs, 0.23 ± 0.07 mm, p=0.008).
CONCLUSIONS
FMD was significantly higher in the warm season than in the cool season when the measurements were performed on the same subjects and a paired comparison was made.
背景
血流介导的血管舒张功能（FMD）的季节性变化仍存在争议。一项大型队列研究表明，FMD在夏季最高，冬季最低，但该研究是在不同季节对不同人群进行横断面研究，并未对同一人群的结果进行比较。
方法
对27例患有高血压、糖尿病和/或高脂血症的门诊患者，在凉爽季节（14.4±4.4°C）和温暖季节（28.8±1.0°C）测量FMD并进行比较。
结果
温暖季节静息肱动脉平均直径显著大于凉爽季节。放气后肱动脉最大直径在温暖季节也显著大于凉爽季节。根据静息直径和最大直径计算得出的FMD，即使以相对值（4.74±2.15对5.71±2.17%，p=0.03）或绝对值（0.18±0.08对0.23±0.07mm，p=0.008）表示，在温暖季节也显著高于凉爽季节。
结论
当对同一受试者进行测量并进行配对比较时，FMD在温暖季节显著高于凉爽季节。
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