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Biochem Biophys Res Commun. 2011 Aug 26;412(2):318-22. doi: 10.1016/j.bbrc.2011.07.092. Epub 2011 Jul 28.
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A cross-sectional evaluation of seasonality as a determinant of endothelial function.横断面评估季节变化作为内皮功能决定因素。
Nitric Oxide. 2011 Oct 30;25(3):282-7. doi: 10.1016/j.niox.2011.05.010. Epub 2011 Jul 3.
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Assessment of flow-mediated dilation in humans: a methodological and physiological guideline.人体血流介导扩张评估：方法学和生理学指南。
Am J Physiol Heart Circ Physiol. 2011 Jan;300(1):H2-12. doi: 10.1152/ajpheart.00471.2010. Epub 2010 Oct 15.
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Ultrasound assessment of flow-mediated dilation.超声评估血流介导的扩张。
Hypertension. 2010 May;55(5):1075-85. doi: 10.1161/HYPERTENSIONAHA.110.150821. Epub 2010 Mar 29.
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Relationship between blood pressure and outdoor temperature in a large sample of elderly individuals: the Three-City study.一项针对大量老年个体的研究：三城市研究中血压与室外温度的关系。
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Hypertens Res. 2008 Nov;31(11):2019-25. doi: 10.1291/hypres.31.2019.
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Relation of season and temperature to endothelium-dependent flow-mediated vasodilation in subjects without clinical evidence of cardiovascular disease (from the Framingham Heart Study).季节和温度与无心血管疾病临床证据受试者的内皮依赖性血流介导的血管舒张之间的关系（来自弗雷明汉心脏研究）
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In vivo mechanisms of cutaneous vasodilation and vasoconstriction in humans during thermoregulatory challenges.人类在体温调节挑战期间皮肤血管舒张和收缩的体内机制。
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Endothelial function and outdoor temperature.内皮功能与室外温度。
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Seasonal variation in blood pressure in man.
Nature. 1961 Jan 21;189:235. doi: 10.1038/189235a0.

在同一受试者中测量的内皮依赖性血流介导的血管舒张的季节性变化。

Seasonal variation of endothelium-dependent flow-mediated vasodilation measured in the same subjects.

作者信息

Iwata Masako, Miyashita Yutaka, Kumagai Hiromichi

出版信息

Am J Cardiovasc Dis. 2012;2(2):111-5. Epub 2012 May 15.

PMID:22720200
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3371618/
Abstract

BACKGROUND

Seasonal variation of flow-mediated vasodilation (FMD) remains controversial. A large cohort study showing that FMD was highest in summer and lowest in winter has been performed in a cross-sectional manner on different populations in different seasons, and the results for the same population were not compared.

METHODS

FMD was compared between the cool season (14.4 ± 4.4°C) and warm season (28.8 ± 1.0°C) in the same 27 outpatients with hypertension, diabetes mellitus and/or hyperlipidemia.

RESULTS

The mean resting brachial artery diameter was significantly larger in the warm season than in the cool season. The maximal post-deflation brachial artery diameter was also significantly larger in the warm season than in the cool season. FMD, which was calculated from the resting diameter and the maximal diameter, was significantly higher in the warm season than in the cool season even when expressed as the relative value (4.74 ± 2.15 vs. 5.71 ± 2.17%, p=0.03) or absolute value (0.18 ± 0.08 vs, 0.23 ± 0.07 mm, p=0.008).

CONCLUSIONS

FMD was significantly higher in the warm season than in the cool season when the measurements were performed on the same subjects and a paired comparison was made.

摘要

背景

血流介导的血管舒张功能（FMD）的季节性变化仍存在争议。一项大型队列研究表明，FMD在夏季最高，冬季最低，但该研究是在不同季节对不同人群进行横断面研究，并未对同一人群的结果进行比较。

方法

对27例患有高血压、糖尿病和/或高脂血症的门诊患者，在凉爽季节（14.4±4.4°C）和温暖季节（28.8±1.0°C）测量FMD并进行比较。

结果

温暖季节静息肱动脉平均直径显著大于凉爽季节。放气后肱动脉最大直径在温暖季节也显著大于凉爽季节。根据静息直径和最大直径计算得出的FMD，即使以相对值（4.74±2.15对5.71±2.17%，p=0.03）或绝对值（0.18±0.08对0.23±0.07mm，p=0.008）表示，在温暖季节也显著高于凉爽季节。

结论

当对同一受试者进行测量并进行配对比较时，FMD在温暖季节显著高于凉爽季节。