Tsai Chia-Wei, Yost Richard A, Garrett Timothy J
Department of Chemistry, University of Florida, FL, USA.
Bioanalysis. 2012 Jun;4(11):1363-75. doi: 10.4155/bio.12.110.
Green chemistry is a way to avoid threats to human health and the environment in chemical processes, including analytical methodology. According to the 12 principles provided by ACS Green Chemistry Institute, first described by Anastas and Warner, prevention of waste generation should be first considered as an alternative to ways of treating waste. Therefore, analytical techniques that may reduce solvent waste are of great interest towards greener analysis. High-field asymmetric waveform ion mobility spectrometry (FAIMS) utilizes electrical fields to achieve separation, post an ionization source, and could provide an alternative method for separation and reduce solvent use in comparison with traditional HPLC methodologies. In this article, the operational principles and developments of FAIMS will be discussed, including the advantages of adding solvent vapor to the carrier gas. In addition, applications and challenges of implementing FAIMS technology will also be discussed.
绿色化学是一种在化学过程（包括分析方法）中避免对人类健康和环境造成威胁的方法。根据美国化学学会绿色化学研究所提出的12条原则（最初由阿纳斯塔斯和华纳描述），应首先考虑防止废物产生，作为处理废物方式的替代方法。因此，可能减少溶剂废物的分析技术对于更绿色的分析具有极大的吸引力。高场不对称波形离子迁移谱（FAIMS）利用电场在电离源之后实现分离，与传统的高效液相色谱方法相比，它可以提供一种分离的替代方法并减少溶剂使用。在本文中，将讨论FAIMS的工作原理和发展，包括在载气中添加溶剂蒸汽的优点。此外，还将讨论实施FAIMS技术的应用和挑战。
