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从氟烷敏感猪骨骼肌分离出的线粒体中与ATP相关反应的损伤。

Impairment of ATP-linked reactions in mitochondria isolated from skeletal muscle of halothane-sensitive pigs.

作者信息

Ayoub S, Monin G, Rock E, Younes A

机构信息

Institut National de Recherche Agronomique (INRA), Ceyrat, France.

出版信息

Cell Biochem Funct. 1990 Oct;8(4):205-10. doi: 10.1002/cbf.290080404.

DOI:10.1002/cbf.290080404
PMID:2272118
Abstract

Oxygen consumption was depressed in mitochondria isolated from halothane sensitive pig (HP) muscle. The calculation of the respiratory control ratio (RCR) indicated that mitochondria were more affected at the site-I level of the respiratory chain. Calcium accumulation in these mitochondria was not altered when driven by the oxidation of succinate. This process was abolished when linked to ATP as a source of energy. ATP transport was completely inhibited in (HP) mitochondria.

摘要

从氟烷敏感猪(HP)肌肉中分离出的线粒体耗氧量降低。呼吸控制率(RCR)的计算表明,线粒体在呼吸链的位点I水平受到的影响更大。当由琥珀酸氧化驱动时,这些线粒体中的钙积累没有改变。当与ATP作为能量来源相联系时,这个过程被消除。ATP转运在(HP)线粒体中被完全抑制。

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