环氧水解酶在脂代谢中的作用。
Role of epoxide hydrolases in lipid metabolism.
机构信息
Department of Entomology and U.C.D. Comprehensive Cancer Center, One Shields Avenue, University of California, Davis, CA 95616, USA.
出版信息
Biochimie. 2013 Jan;95(1):91-5. doi: 10.1016/j.biochi.2012.06.011. Epub 2012 Jun 18.
Abstract
Epoxide hydrolases (EH), enzymes present in all living organisms, transform epoxide-containing lipids to 1,2-diols by the addition of a molecule of water. Many of these oxygenated lipid substrates have potent biological activities: host defense, control of development, regulation of blood pressure, inflammation, and pain. In general, the bioactivity of these natural epoxides is significantly reduced upon metabolism to diols. Thus, through the regulation of the titer of lipid epoxides, EHs have important and diverse biological roles with profound effects on the physiological state of the host organism. This review will discuss the biological activity of key lipid epoxides in mammals. In addition, the use of EH specific inhibitors will be highlighted as possible therapeutic disease interventions.
摘要
环氧化物水解酶（EH）存在于所有生物体中，通过添加一个水分子将含环氧的脂质转化为 1,2-二醇。许多这些含氧脂质底物具有很强的生物学活性：宿主防御、发育控制、血压调节、炎症和疼痛。一般来说，这些天然环氧化物在代谢为二醇后，其生物活性会显著降低。因此，EH 通过调节脂质环氧化物的含量，在宿主生物体的生理状态方面具有重要而多样的生物学作用。本综述将讨论哺乳动物中环氧化物的生物活性。此外，还将强调 EH 特异性抑制剂的应用作为可能的治疗疾病干预措施。
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