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Metformin pathways: pharmacokinetics and pharmacodynamics.

作者信息

Gong Li, Goswami Srijib, Giacomini Kathleen M, Altman Russ B, Klein Teri E

机构信息

Department of Genetics, Stanford University Medical Center, Stanford University, Stanford, California 94304, USA.

出版信息

Pharmacogenet Genomics. 2012 Nov;22(11):820-7. doi: 10.1097/FPC.0b013e3283559b22.

DOI:10.1097/FPC.0b013e3283559b22
PMID:22722338
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3651676/
Abstract
摘要

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The role of ATM in response to metformin treatment and activation of AMPK.ATM在应对二甲双胍治疗及激活AMPK中的作用。
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Cellular and molecular mechanisms of metformin: an overview.二甲双胍的细胞和分子机制：概述。
Clin Sci (Lond). 2012 Mar;122(6):253-70. doi: 10.1042/CS20110386.
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Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney.西咪替丁在肾脏引起的药代动力学药物相互作用的可能机制是多药和毒素外排泵对腔侧外排的竞争性抑制，而不是有机阳离子转运蛋白 2 对基底外侧摄取的抑制。
J Pharmacol Exp Ther. 2012 Feb;340(2):393-403. doi: 10.1124/jpet.111.184986. Epub 2011 Nov 9.
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The pharmacogenetics of metformin and its impact on plasma metformin steady-state levels and glycosylated hemoglobin A1c.二甲双胍的药物遗传学及其对血浆二甲双胍稳态水平和糖化血红蛋白 A1c 的影响。
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Clin Pharmacol Ther. 2011 Nov;90(5):674-84. doi: 10.1038/clpt.2011.165. Epub 2011 Sep 28.
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Effects of a MATE protein inhibitor, pyrimethamine, on the renal elimination of metformin at oral microdose and at therapeutic dose in healthy subjects.MATE 蛋白抑制剂（乙胺嘧啶）对健康受试者口服微剂量和治疗剂量二甲双胍肾清除率的影响。
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