Watanabe M, Taketa K, Fujii K, Fujii C, Kono H
Acta Med Okayama. 1979 Jun;33(3):189-96.
An unusual lipoprotein pattern on polyacrylamide-gel disc-electrophoresis was observed in 37 year-old male diagnosed as alcoholic liver injury. The electrophoretic lipoprotein pattern consisted of a major band of pre-beta mobility and minor intermediate, fast-beta and slow-alpha bands. The normal beta band was virtually absent and the alpha band was diminished. The abnormal lipoprotein pattern was observed one week after discontinuing alcohol consumption when marked hypertriglyceridemia demonstrated earlier had already normalized leaving a moderate hypercholesterolemia with reduced esterified cholesterol and abnormal liver function tests. The lipoprotein abnormalities were completely normal one month later. The appearance of a major pre-beta band with normal triglyceride and high cholesterol levels is discussed in relation to the formation of larger triglyceride-rich LDL particles in recovery from alcoholic hepatitis.
在一名被诊断为酒精性肝损伤的37岁男性患者中，观察到其聚丙烯酰胺凝胶圆盘电泳上呈现出异常的脂蛋白模式。电泳脂蛋白模式由一条主要的前β迁移率带以及次要的中间带、快速β带和慢速α带组成。正常的β带几乎缺失，α带减少。在停止饮酒一周后观察到这种异常脂蛋白模式，此时先前表现出的明显高甘油三酯血症已经恢复正常，仅留下中度高胆固醇血症，伴有酯化胆固醇降低和肝功能检查异常。一个月后脂蛋白异常完全恢复正常。结合酒精性肝炎恢复过程中形成更大的富含甘油三酯的低密度脂蛋白颗粒，讨论了出现主要前β带且甘油三酯水平正常但胆固醇水平高的情况。
