Mordasini R C, Berthold S, Schlumpf E, Riva G
Schweiz Med Wochenschr. 1976 Aug 28;106(35):1173-82.
In 50 patients with acute hepatitis serum lipide and lipoproteins were determined at regular intervals and the results were compared with the usual liver function tests. Australia-antigen was established in 26 patients. During the first three weeks of the disease the most striking finding was a significant increase in the triglycerides, which was most pronounced at the end of the second week. Triglyceride levels usually returned to normal during the fourth week. In the course of the disease, lipoprotein electrophoresis showed marked decrease or absence of alpha- and pre-beta-lipoproteins during the first two weeks. During the third week faint alpha and pre-beta bands recurred in most patients. By the end of the fourth week lipoprotein electrophoretic findings were back to normal. There was general correlation between routine tests of liver function and results of lipid analyses throughout the course of the disease. This typical pattern of serum lipid and lipoprotein changes was found with near-consistency in patients with HAA-positive hepatitis. It was also present in the majority of HAA-negative patients, though in these the characteristic discrepancy between hypertriglyceridemia and simultaneous decrease of the pre-beta-lipoprotein band in eletrophoresis was, on the average, absent.
对50例急性肝炎患者定期测定血清脂质和脂蛋白，并将结果与常规肝功能检查结果进行比较。26例患者检测到澳大利亚抗原。在疾病的前三周，最显著的发现是甘油三酯显著升高，在第二周结束时最为明显。甘油三酯水平通常在第四周恢复正常。在疾病过程中，脂蛋白电泳显示在最初两周α-脂蛋白和前β-脂蛋白显著减少或缺失。在第三周，大多数患者出现微弱的α-脂蛋白和前β-脂蛋白条带。到第四周结束时，脂蛋白电泳结果恢复正常。在疾病全过程中，肝功能常规检查与脂质分析结果之间存在普遍相关性。在澳大利亚抗原阳性的肝炎患者中，血清脂质和脂蛋白变化的这种典型模式几乎一致。在大多数澳大利亚抗原阴性的患者中也存在这种情况，不过在这些患者中，平均而言不存在高甘油三酯血症与电泳中前β-脂蛋白条带同时减少之间的特征性差异。
