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[瑞典无烟烟草“鼻烟”的不良反应]

[Adverse effects of Swedish smokeless tobacco "snus"].

作者信息

Wickholm Seppo, Lahtinen Aira, Ainamo Anja, Rautalahti Matti

机构信息

Johnson & Johnson Consumer Nordic, Karolinska Institutet, hammaslääketieteen osasto, parodontologia, PL 4064, SE-141 04 Huddinge, Sverige.

出版信息

Duodecim. 2012;128(10):1089-96.

Abstract

Selling smokeless tobacco (snus) in Finland is illegal, yet one-third of all males aged 16 to 18 years have tried it. A regular snus user can receive a daily dose of 60 to 150 milligrams of nicotine and become heavily addicted. The first--and easily detectable--lesions appear in the oral mucosa and gingiva. Long-time followup studies of snus use from a young age are, however, still lacking. Evidence exists of increased risk for fatal cardiovascular diseases and increased risk for injuries. Risk for oral cancer is debated, with more studies showing an increased risk than showing no risk; risk also exists for cancer of esophagus, stomach and pancreas. A new and alarming finding among female users is increased risk for preterm birth, preeclampsia and neonatal apnea.

摘要

在芬兰,销售无烟烟草(鼻烟)是非法的,但16至18岁的男性中有三分之一尝试过。经常使用鼻烟的人每天可摄入60至150毫克尼古丁,并极易上瘾。最初且易于察觉的病变出现在口腔黏膜和牙龈。然而,仍缺乏对年轻时就开始使用鼻烟的长期随访研究。有证据表明,使用鼻烟会增加致命心血管疾病的风险以及受伤风险。口腔癌的风险存在争议,更多研究表明风险增加而非没有风险;食管癌、胃癌和胰腺癌的风险也存在。女性使用者中一个新的惊人发现是早产、先兆子痫和新生儿呼吸暂停的风险增加。

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