de Gandarias J M, Ramirez M, Echevarria E, Irazusta J, Casis L
Department of Physiology, Medical School, University of Pais Vasco, Bilbao, Spain.
Gen Physiol Biophys. 1990 Aug;9(4):385-9.
Research into the functional role of brain peptides is performed, in part, by studying peptidase enzymes which might be involved in the processing or inactivation of the brain peptides. Aminopeptidase activity has been proposed as a candidate for the regulation of the degradation of these peptides. In this paper, acid (Asp-) and basic (Arg-) aminopeptidase activities were studied in several brain regions and in the serum during the estrous cycle of the rat. Asp-aminopeptidase activity did not significantly change at any point. However, a marked rise was found in Arg-aminopeptidase activity in all the brain areas studied and the serum during the proestrus. It is suggested that this activity plays a role in the hormonal changes that take place during the cycle, possibly in regulating the activity of several neuroactive peptides.
对脑肽功能作用的研究，部分是通过研究可能参与脑肽加工或失活的肽酶来进行的。氨肽酶活性已被提出作为调节这些肽降解的一个候选因素。在本文中，研究了大鼠发情周期中几个脑区和血清中的酸性（天冬氨酸型 -）和碱性（精氨酸型 -）氨肽酶活性。天冬氨酸型氨肽酶活性在任何时候都没有显著变化。然而，在动情前期，所研究的所有脑区和血清中的精氨酸型氨肽酶活性都有显著升高。有人认为这种活性在发情周期中发生的激素变化中起作用，可能在调节几种神经活性肽的活性方面发挥作用。
