Division of Clinical Veterinary Sciences, Royal (Dick) School of Veterinary Studies and the Roslin Institute, The University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian, UK.
Transbound Emerg Dis. 2013 Aug;60(4):338-44. doi: 10.1111/j.1865-1682.2012.01352.x. Epub 2012 Jun 21.
The aim of this study was to estimate the incidence of mycobacterial infections in cats in Great Britain (GB). This was performed using the proxy measure of feline tissue samples submitted to diagnostic laboratories in GB that were found to have histopathological changes typical of mycobacterial infection ('MYC'). Sixteen primary diagnostic laboratories were asked for information on the number of feline samples submitted in 2009, the number with MYC, the number undergoing Ziehl-Neelsen (ZN) staining and, for comparison, the number diagnosed with lymphoma. Eight laboratories provided full data for the whole year: 11,782 samples; lymphoma 3.2% (mean, 95% CI: 2.89, 3.5), MYC 1.16% (0.98; 1.37) and ZN-positive 0.31% (0.22; 0.43). Data on 1569 samples from seven laboratories that provided partial data on samples for the whole year revealed similar results, although all changes were more frequent: lymphoma 5.42% (4.35; 6.66), MYC 2.36% (1.66; 3.23) and ZN-positive 0.77% (0.40; 1.33). One laboratory only provided data for part of the year (4.5 months), reporting all three types of histopathology less frequently: 18,232 samples; lymphoma 0.2% (0.18; 0.32), MYC 0.07% (0.04; 0.12) and ZN-positive 0.05% (0.02; 0.09). The reasons for low reporting rates in this high-throughput laboratory are unclear. In total, 187 samples were reported as having MYC. Five Reference laboratories were also contacted, reporting 174 feline tissue submissions in 2009, with mycobacteria being cultured from 90. The study shows that MYC are frequently reported in tissue samples from cats in GB, being reported in ~1% of samples, with confirmation as ZN-positive in ~0.3%. Lymphoma is recognized as a common disease in cats, being seen in ~3% of samples in this study. When compared against MYC, lymphoma was reported only twice as frequently. This confirms that far from being rare, clinically significant mycobacterial infections occur commonly in cats in GB.
本研究旨在估计英国（GB）猫分枝杆菌感染的发病率。这是通过使用代理指标来完成的，即英国诊断实验室提交的猫组织样本中发现有分枝杆菌感染的组织病理学变化（“MYC”）。 16 个初级诊断实验室被要求提供 2009 年提交的猫样本数量、有 MYC 的数量、进行 Ziehl-Neelsen（ZN）染色的数量以及作为比较的淋巴瘤数量的信息。 8 个实验室提供了全年的完整数据：11782 个样本；淋巴瘤 3.2%（平均值，95%CI：2.89，3.5），MYC 1.16%（0.98；1.37），ZN 阳性 0.31%（0.22；0.43）。提供全年部分数据的 7 个实验室的 1569 个样本数据显示出类似的结果，尽管所有变化都更为频繁：淋巴瘤 5.42%（4.35；6.66），MYC 2.36%（1.66；3.23）和 ZN 阳性 0.77%（0.40；1.33）。一个实验室仅提供了部分年份（4.5 个月）的数据，报告的所有三种组织病理学都较少：18232 个样本；淋巴瘤 0.2%（0.18；0.32），MYC 0.07%（0.04；0.12）和 ZN 阳性 0.05%（0.02；0.09）。高吞吐量实验室低报告率的原因尚不清楚。总共报告了 187 个有 MYC 的样本。还联系了 5 个参考实验室，报告了 2009 年 174 份猫组织样本提交，从其中 90 份培养出了分枝杆菌。研究表明，在英国的猫组织样本中经常报告有 MYC，约 1%的样本有报告，ZN 阳性的确认率约为 0.3%。淋巴瘤被认为是猫的一种常见疾病，在本研究中约占 3%的样本。与 MYC 相比，淋巴瘤的报告频率仅为其两倍。这证实了在英国，临床上有意义的分枝杆菌感染在猫中很常见，而不是罕见。
