Černá Petra, Mitchell Jordan L, Lodzinska Joanna, Cazzini Paola, Varjonen Katarina, Gunn-Moore Danièlle A
Department of Clinical Sciences, Colorado State University, Fort Collins, Colorado, CO 80528, USA.
The University of Veterinary and Pharmaceutical Sciences Brno, 612 42 Brno, Czech Republic.
Pathogens. 2020 Nov 18;9(11):959. doi: 10.3390/pathogens9110959.
Mycobacterial infections are a major concern in veterinary medicine because of the difficulty achieving an etiological diagnosis, the challenges and concerns of treatment, and the potential zoonotic risk. , a slow-growing non-tuberculous mycobacteria, causes disease in both humans and animals. While infections have been well described in humans, where it may be misdiagnosed as tuberculosis, there are fewer reports in animals. Only four cases have been reported in the domestic cat. This case report describes systemic infection in two sibling indoor-only cats that presented two and half years apart with cutaneous disease that was found to be associated with osteolytic and pulmonary pathology. Infection with was confirmed in both cats by polymerase chain reaction on fine-needle aspirate of a lumbosacral soft tissue mass in one cat and on a tissue punch biopsy of a skin lesion in the other; interferon-gamma release assay inferred -complex and -complex infection in the two cats, respectively. Both patients made a full recovery following antimicrobial therapy with rifampicin, azithromycin, and pradofloxacin (plus N-acetyl cysteine in cat 2). This report highlights successful treatment of systemic mycobacteriosis in the cat and the challenge of accurately diagnosing this infection.
分枝杆菌感染是兽医学中的一个主要问题，因为病因诊断困难、治疗面临挑战且存在人畜共患病风险。，一种生长缓慢的非结核分枝杆菌，可导致人类和动物患病。虽然人类感染已有详细描述，可能被误诊为结核病，但动物感染的报道较少。家猫中仅报道过4例。本病例报告描述了两只同窝的室内猫的全身感染，它们分别在两年半的时间里出现皮肤疾病，并伴有溶骨性和肺部病变。通过对一只猫腰骶部软组织肿块的细针穿刺抽吸物以及另一只猫皮肤病变的组织块活检进行聚合酶链反应，证实两只猫均感染了。干扰素-γ释放试验分别推断两只猫感染了-复合体和-复合体。两只猫在接受利福平、阿奇霉素和普拉德氟沙星抗菌治疗（猫2加用N-乙酰半胱氨酸）后均完全康复。本报告强调了猫全身分枝杆菌病的成功治疗以及准确诊断这种感染的挑战。
