Center for Heart Failure Research, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands.
Trends Mol Med. 2012 Jul;18(7):426-37. doi: 10.1016/j.molmed.2012.05.005. Epub 2012 Jun 20.
Viral myocarditis is an important cause of heart failure for which no specific treatments are available. Direct viral injury to cardiac cells provokes an inflammatory response that significantly contributes to cardiac damage and ensuing morbidity. Despite the central pathogenic role of autoimmune injury, broad inhibition of the inflammatory response does not result in patient benefit. Many preclinical studies collectively emphasize that modulating distinct inflammatory signaling pathways may yield effective viral clearance while preserving cardiac structure. This review aims to provide an overview of the sometimes contrasting observations from experimental viral myocarditis models and to translate the lessons learned into opportunities for future investigations and therapies.
病毒性心肌炎是心力衰竭的一个重要病因，但目前尚无特效治疗方法。病毒直接损伤心肌细胞会引发炎症反应，这对心肌损伤和随后的发病率有重要影响。尽管自身免疫损伤起着关键的致病作用，但广泛抑制炎症反应并不能使患者受益。许多临床前研究共同强调，调节不同的炎症信号通路可能会有效地清除病毒，同时保留心脏结构。本综述旨在概述实验性病毒性心肌炎模型中的一些相互矛盾的观察结果，并将这些经验教训转化为未来研究和治疗的机会。
