囊泡包被成分和多亚基连接复合物的结构与机制。
Structures and mechanisms of vesicle coat components and multisubunit tethering complexes.
机构信息
Cambridge Institute for Medical Research, Department of Clinical Biochemistry, University of Cambridge, Cambridge CB2 0XY, UK.
出版信息
Curr Opin Cell Biol. 2012 Aug;24(4):475-83. doi: 10.1016/j.ceb.2012.05.013. Epub 2012 Jun 22.
Abstract
Eukaryotic cells face a logistical challenge in ensuring prompt and precise delivery of vesicular cargo to specific organelles within the cell. Coat protein complexes select cargo and initiate vesicle formation, while multisubunit tethering complexes participate in the delivery of vesicles to target membranes. Understanding these macromolecular assemblies has greatly benefited from their structural characterization. Recent structural data highlight principles in coat recruitment and uncoating in both the endocytic and retrograde pathways, and studies on the architecture of tethering complexes provide a framework for how they might link vesicles to the respective acceptor compartments and the fusion machinery.
摘要
真核细胞在确保囊泡货物迅速而精确地递送到细胞内特定细胞器方面面临着一个物流方面的挑战。衣壳蛋白复合物选择货物并启动囊泡形成，而多亚基连接复合物则参与囊泡向靶膜的运输。对这些大分子组装体的结构特征的了解极大地促进了对它们的理解。最近的结构数据突出了内吞作用和逆行途径中衣壳募集和去衣壳的原则，对连接复合物结构的研究为它们如何将囊泡与相应的受体隔室和融合机制连接起来提供了一个框架。
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