囊泡包被与 Rab 介导的囊泡靶向之间的新联系。
New links between vesicle coats and Rab-mediated vesicle targeting.
机构信息
Department of Biochemistry, University of Washington School of Medicine, Seattle, WA 98195-3750, USA.
出版信息
Semin Cell Dev Biol. 2011 Feb;22(1):18-26. doi: 10.1016/j.semcdb.2010.07.003. Epub 2010 Jul 17.
Abstract
Vesicle trafficking is a highly regulated process that transports proteins and other cargoes through eukaryotic cells while maintaining cellular organization and compartmental identity. In order for cargo to reach the correct destination, each step of trafficking must impart specificity. During vesicle formation, this is achieved by coat proteins, which selectively incorporate cargo into the nascent vesicle. Classically, vesicle coats are thought to dissociate shortly after budding. However, recent studies suggest that coat proteins can remain on the vesicle en route to their destination, imparting targeting specificity by physically and functionally interacting with Rab-regulated tethering systems. This review focuses on how interactions among Rab GTPases, tethering factors, SNARE proteins, and vesicle coats contribute to vesicle targeting, fusion, and coat dynamics.
摘要
囊泡运输是一个高度调控的过程，它在维持细胞组织和区隔特性的同时，将蛋白质和其他货物运输穿过真核细胞。为了使货物到达正确的目的地，运输的每一步都必须具有特异性。在囊泡形成过程中，这是通过衣被蛋白来实现的，衣被蛋白选择性地将货物纳入新生囊泡。传统上认为，囊泡衣被在出芽后不久就会解离。然而，最近的研究表明，衣被蛋白可以在囊泡运输过程中留在囊泡上，通过与 Rab 调节的连接系统物理和功能相互作用，赋予靶向特异性。本综述重点讨论了 Rab GTPases、连接因子、SNARE 蛋白和囊泡衣被之间的相互作用如何促进囊泡的靶向、融合和衣被动力学。
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