Paul E, Müllhofer R
Hautklinik, am Klinikum Nürnberg.
Hautarzt. 1990 Aug;41(8):432-7.
Among a total of 1426 patients with malignant melanoma, the site of the primary tumor was unknown in 24 patients (1.7%), most of whom were male (20 of these 24 patients were male, the remaining 4, female). The average age of these 24 patients correlates with the age distribution of the 1426 patients. In half the patients under scrutiny, the first metastases were found in lymph nodes, and one quarter of these developed metastases to the brain or skin. The 21 patients it was possible to follow up over the entire period of their case history had a poor prognosis. The 5-year survival rate after excision of the first metastases was only 14%. In 8 patients the medical history indicated a previous pigmented tumour on the skin. In 4 of these patients melanophages were also found within depigmented scars located in the drainage area of the lymph nodes involved. However, there were no signs of a primary tumour either on the mucous membranes or in the eyes in any of the other patients.
在总共1426例恶性黑色素瘤患者中，24例（1.7%）患者的原发肿瘤部位不明，其中大多数为男性（这24例患者中有20例为男性，其余4例为女性）。这24例患者的平均年龄与1426例患者的年龄分布相关。在接受检查的患者中，一半患者的首次转移发生在淋巴结，其中四分之一发生了脑或皮肤转移。在整个病史期间能够进行随访的21例患者预后较差。首次转移灶切除后的5年生存率仅为14%。8例患者的病史显示曾有皮肤色素沉着肿瘤。在其中4例患者中，在受累淋巴结引流区域的色素脱失瘢痕内也发现了噬黑素细胞。然而，其他任何患者的黏膜或眼睛均未发现原发肿瘤的迹象。
