Khasanov Sh R, Iavorskiĭ V V, Demidov L V
Vopr Onkol. 1987;33(3):36-9.
Out of 3,822 cases of malignant skin melanoma from an unknown primary site, metastases were registered in 53 (1.4%). The male/female ratio was 3:1. The rates of 3-, 5- and 10-year survival were evaluated versus sex, time to treatment, metastatic site and therapeutic modality. The shortest survival was associated with metastasis into cervical lymph nodes, while the longest one (with an overall 3-year survival rate of 40%)--with involvement of a single lymphatic zone. The latter group should be given a complex treatment including a standard regional lymphadenectomy with adjuvant chemo- and immunotherapy. Such treatment resulted in a 3-year survival in 50% of cases. The overall survival rates in patients with metastasis of malignant skin melanoma with an unknown primary site were 29% at 3 years, 26.5%--at 5 and 23.2% at 10 years.
在3822例原发部位不明的恶性皮肤黑色素瘤病例中，有53例（1.4%）出现转移。男女比例为3:1。对3年、5年和10年生存率进行了评估，评估因素包括性别、治疗时间、转移部位和治疗方式。最短生存期与颈部淋巴结转移相关，而最长生存期（总体3年生存率为40%）与单个淋巴区域受累相关。后一组应接受包括标准区域淋巴结清扫术及辅助化疗和免疫治疗在内的综合治疗。这种治疗使50%的病例存活了3年。原发部位不明的恶性皮肤黑色素瘤转移患者的总体生存率在3年时为29%，5年时为26.5%，10年时为23.2%。
