复方苦参注射液的抗氧化及免疫活性。
Antioxidant and immunity activities of Fufang Kushen Injection Liquid.
机构信息
Department of Gastrointestinal Surgery, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, Linhai 318000, Zhejiang, China.
出版信息
Molecules. 2012 May 30;17(6):6481-90. doi: 10.3390/molecules17066481.
Abstract
We investigated the effects of Fufang Kushen Injection Liquid (FFKSIL) on gastric immunity and oxidant-antioxidant status during N-methyl-N′-nitro-N-nitroso-guanidine (MNNG)-induced gastric carcinogenesis. The extent of lipid peroxidation and the levels of reduced glutathione (GSH) and activities of the GSH-dependent enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) were used to monitor the peroxidative balance. Enhanced lipid peroxidation in the gastric cancer animals was accompanied by significant decreases in the activities of GSH, GPx, GST and GR. Administration of FFKSIL significantly enhanced serum IgA, IgG, IgM, IL-2, IL-4 and IL-10 levels, decreased serum IL-6 and TNF-α levels, lowered the levels of lipid peroxides and enhanced GSH levels and activities of GSH-dependent enzymes. Our results suggest that FFKSIL blocks experimental gastric carcinogenesis by protecting against carcinogen-induced oxidative damage and improving immunity activity.
摘要
我们研究了复方苦参注射液（FFKSIL）在 N-甲基-N′-硝基-N-亚硝基胍（MNNG）诱导的胃癌发生过程中对胃免疫和氧化还原状态的影响。我们使用脂质过氧化程度、还原型谷胱甘肽（GSH）水平以及谷胱甘肽依赖酶超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GSH-Px）的活性来监测过氧化平衡。胃癌动物的脂质过氧化增强伴随着 GSH、GPx、GST 和 GR 活性的显著降低。FFKSIL 的给药显著增强了血清 IgA、IgG、IgM、IL-2、IL-4 和 IL-10 水平，降低了血清 IL-6 和 TNF-α 水平，降低了脂质过氧化物水平，增强了 GSH 水平和 GSH 依赖酶的活性。我们的结果表明，FFKSIL 通过防止致癌物引起的氧化损伤和提高免疫活性来阻止实验性胃癌的发生。
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