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Development of monoclonal antibodies to rohu [Labeo rohita] immunoglobulins for use in immunoassays.开发用于免疫测定的针对印度鲤[印度裂唇鱼]免疫球蛋白的单克隆抗体。
Fish Shellfish Immunol. 2008 Dec;25(6):761-74. doi: 10.1016/j.fsi.2008.02.014. Epub 2008 Mar 4.
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The pulpal origin of immunoglobulins in dentin beneath caries: an immunohistochemical study.
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Interleukin-6.白细胞介素-6
Crit Care Med. 2005 Dec;33(12 Suppl):S463-5. doi: 10.1097/01.ccm.0000186784.62662.a1.
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The role of IL-6 and STAT3 in inflammation and cancer.白细胞介素-6和信号转导及转录激活因子3在炎症和癌症中的作用。
Eur J Cancer. 2005 Nov;41(16):2502-12. doi: 10.1016/j.ejca.2005.08.016. Epub 2005 Sep 30.
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Regulation of IL4 gene expression by T cells and therapeutic perspectives.
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Oxidative stress has a role in malignant transformation in Barrett's oesophagus.氧化应激在巴雷特食管的恶性转化中起作用。
Int J Cancer. 2002 Dec 20;102(6):551-5. doi: 10.1002/ijc.10755.
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Human leukocyte antigens class II and tumor necrosis factor genetic polymorphisms are independent predictors of non-Hodgkin lymphoma outcome.人类白细胞抗原II类和肿瘤坏死因子基因多态性是非霍奇金淋巴瘤预后的独立预测指标。
Blood. 2002 Oct 15;100(8):3037-40. doi: 10.1182/blood-2002-02-0654.
8
Chronic treatment with trans resveratrol prevents intracerebroventricular streptozotocin induced cognitive impairment and oxidative stress in rats.白藜芦醇对大鼠进行长期治疗可预防脑室内注射链脲佐菌素诱导的认知障碍和氧化应激。
Life Sci. 2002 Oct 11;71(21):2489-98. doi: 10.1016/s0024-3205(02)02083-0.
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Prospects for chemoprevention of cancer.癌症化学预防的前景。
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The gastrointestinal tract: a major site of antioxidant action?胃肠道：抗氧化作用的主要部位？
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复方苦参注射液的抗氧化及免疫活性。

Antioxidant and immunity activities of Fufang Kushen Injection Liquid.

机构信息

Department of Gastrointestinal Surgery, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, Linhai 318000, Zhejiang, China.

出版信息

Molecules. 2012 May 30;17(6):6481-90. doi: 10.3390/molecules17066481.

DOI:10.3390/molecules17066481
PMID:22728348
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6268272/
Abstract

We investigated the effects of Fufang Kushen Injection Liquid (FFKSIL) on gastric immunity and oxidant-antioxidant status during N-methyl-N′-nitro-N-nitroso-guanidine (MNNG)-induced gastric carcinogenesis. The extent of lipid peroxidation and the levels of reduced glutathione (GSH) and activities of the GSH-dependent enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) were used to monitor the peroxidative balance. Enhanced lipid peroxidation in the gastric cancer animals was accompanied by significant decreases in the activities of GSH, GPx, GST and GR. Administration of FFKSIL significantly enhanced serum IgA, IgG, IgM, IL-2, IL-4 and IL-10 levels, decreased serum IL-6 and TNF-α levels, lowered the levels of lipid peroxides and enhanced GSH levels and activities of GSH-dependent enzymes. Our results suggest that FFKSIL blocks experimental gastric carcinogenesis by protecting against carcinogen-induced oxidative damage and improving immunity activity.

摘要

我们研究了复方苦参注射液（FFKSIL）在 N-甲基-N′-硝基-N-亚硝基胍（MNNG）诱导的胃癌发生过程中对胃免疫和氧化还原状态的影响。我们使用脂质过氧化程度、还原型谷胱甘肽（GSH）水平以及谷胱甘肽依赖酶超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GSH-Px）的活性来监测过氧化平衡。胃癌动物的脂质过氧化增强伴随着 GSH、GPx、GST 和 GR 活性的显著降低。FFKSIL 的给药显著增强了血清 IgA、IgG、IgM、IL-2、IL-4 和 IL-10 水平，降低了血清 IL-6 和 TNF-α 水平，降低了脂质过氧化物水平，增强了 GSH 水平和 GSH 依赖酶的活性。我们的结果表明，FFKSIL 通过防止致癌物引起的氧化损伤和提高免疫活性来阻止实验性胃癌的发生。