Tamimi R M, Lagiou P, Adami H-O, Trichopoulos D
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
J Intern Med. 2002 Apr;251(4):286-300. doi: 10.1046/j.1365-2796.2002.00969.x.
The recent progress in molecular biology and pharmacology has increased the likelihood that cancer prevention will rely increasingly on interventions collectively termed 'chemoprevention'. Cancer chemoprevention is the use of agents to inhibit, delay or reverse carcinogenesis. A number of potential targets for chemoprevention have recently been identified. Many classes of agents including antioestrogens, anti-inflammatories, antioxidants and other diet-derived agents have shown a great deal of promise. In this review, we will begin by describing the general classes of chemopreventive agents and the mechanisms by which these agents act. We will then describe the opportunities that presently exist for chemoprevention of specific cancers.
分子生物学和药理学的最新进展增加了癌症预防越来越依赖于统称为“化学预防”的干预措施的可能性。癌症化学预防是指使用药物来抑制、延缓或逆转致癌作用。最近已经确定了一些化学预防的潜在靶点。包括抗雌激素、抗炎药、抗氧化剂和其他饮食衍生药物在内的许多类药物都显示出了很大的前景。在这篇综述中，我们将首先描述化学预防药物的一般类别以及这些药物的作用机制。然后我们将描述目前在特定癌症化学预防方面存在的机会。
