Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Road, Wuhan 430000, China.
Computer Management Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Road, Wuhan 430000, China.
Int J Biol Macromol. 2014 Jul;68:113-6. doi: 10.1016/j.ijbiomac.2014.04.038. Epub 2014 Apr 24.
In the last three decades, numerous polysaccharides and polysaccharide-protein complexes have been isolated from plant or animal and used as a promising source of therapeutic agents for cancer. In this study, we examined the effects of Purslane polysaccharides (PPs) on the oxidative injury and immune status in N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced gastric cancer rats. PPs administration (200, 400 or 800mg/kg body weight) could not only increase the body weight, peripheral white blood cells (WBC) count, thymus and spleen indexes, but also remarkably promote splenocytes proliferation of gastric cancer rats. Furthermore, the production of serum cytokines in gastric cancer rats, such as interleukin-2 (IL-2), interleukin-4 (IL-4) and tumor necrosis factor-alpha (TNF-α) was enhanced by PPs treatment. Besides, treatment with PPs was found to provide a dose-dependent protection against MNNG-induced oxidative injury by enhancing SOD, CAT, GSH-Px activities of gastric cancer rats. Taken together, we concluded that enhancement of antioxidants and immune response might be responsible for the anticancer effect of PPs in gastric cancer.
在过去的三十年中，已经从植物或动物中分离出许多多糖和多糖 - 蛋白质复合物，并将其用作癌症治疗药物的有前途的来源。在这项研究中，我们研究了马齿苋多糖（PPs）对 N-甲基-N'-硝基-N-亚硝基胍（MNNG）诱导的胃癌大鼠氧化损伤和免疫状态的影响。PPs 给药（200、400 或 800mg/kg 体重）不仅可以增加体重、外周白细胞（WBC）计数、胸腺和脾脏指数，而且还可以显著促进胃癌大鼠脾细胞增殖。此外，PPs 处理还增强了血清细胞因子的产生，如白细胞介素 2（IL-2）、白细胞介素 4（IL-4）和肿瘤坏死因子-α（TNF-α）。此外，发现 PPs 通过增强胃癌大鼠 SOD、CAT、GSH-Px 的活性，对 MNNG 诱导的氧化损伤提供了剂量依赖性保护。综上所述，我们得出结论，增强抗氧化剂和免疫反应可能是 PPs 在胃癌中抗癌作用的原因。
