Teragaki Masakazu, Kawano Hitomi, Makino Ryojiro, Inoue Keisuke, Sai Yoshinori, Hosono Mitsuharu, Suehiro Shigefumi, Okamura Mikio
Division of Cardiology, Department of Internal Medicine, Ohno Memorial Hospital, Japan.
Intern Med. 2012;51(12):1627-9. doi: 10.2169/internalmedicine.51.7138. Epub 2012 Jun 15.
Warfarin is widely used in clinical practice all over the world. We report a man in whom prominent eosinophilia appeared after the initiation of warfarin administration following aortic valve replacement. Laboratory data following the administration and discontinuation of warfarin suggested that this drug was responsible for the eosinophilia. It is important to recognize the possibility of warfarin-induced hypereosinophilia as a latent adverse effect even when there are no clinical signs or symptoms.
华法林在全球临床实践中广泛应用。我们报告了一名男子，在主动脉瓣置换术后开始使用华法林后出现显著的嗜酸性粒细胞增多。华法林给药及停药后的实验室数据表明，这种药物是嗜酸性粒细胞增多的原因。即使没有临床体征或症状，认识到华法林诱导的嗜酸性粒细胞增多作为一种潜在不良反应的可能性也很重要。
