Goudarzipour Kourosh, Ghazizadeh Farid, Hoseini Tavassol Hesameddin, Behnam Behdad
Pediatric Congenital Hematologic Disorders Research Center of Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Functional Neurosurgery Research Center, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iran J Pharm Res. 2015 Summer;14(3):887-90.
An important complication of chemotherapy is thromboembolic events that can occur during treatment course. In this way, Warfarin can be used as an efficient prophylactic agent to prevent these complications. Although bleeding is a common adverse effect of Warfarin, eosinophilia is a rare side effect of this drug. We have reported a 5-year-old boy with Burkitt lymphoma who underwent chemotherapy. In the course of chemotherapy, because of thrombosis of the left jugular vein, we initiated Warfarin as a prophylactic drug for TEE secondary to chemotherapy. Following Warfarin initiation, eosinophilia appeared and subsequent to cessation of drug, eosinophilia disappeared. This case is presented to point out physicians to consider eosinophilia as a rare adverse-effect of Warfarin and monitor blood cell differentiation regularly during the course of treatment with this drug.
化疗的一个重要并发症是在治疗过程中可能发生的血栓栓塞事件。因此，华法林可作为一种有效的预防药物来预防这些并发症。尽管出血是华法林常见的不良反应，但嗜酸性粒细胞增多是该药物罕见的副作用。我们报告了一名5岁患有伯基特淋巴瘤的男孩，他接受了化疗。在化疗过程中，由于左颈静脉血栓形成，我们开始使用华法林作为化疗继发血栓栓塞事件的预防药物。开始使用华法林后，出现了嗜酸性粒细胞增多，停药后嗜酸性粒细胞增多消失。本文报告此病例是为了提醒医生，应将嗜酸性粒细胞增多视为华法林罕见的不良反应，并在使用该药物治疗过程中定期监测血细胞分化情况。
