Kuhnt D, Anke T, Besl H, Bross M, Herrmann R, Mocek U, Steffan B, Steglich W
Lehrbereich Biotechnologie der Universität, Kaiserslautern, FRG.
J Antibiot (Tokyo). 1990 Nov;43(11):1413-20. doi: 10.7164/antibiotics.43.1413.
Three new inhibitors of cholesterol biosynthesis have been isolated from cultures of Xerula melanotricha and their structures elucidated by spectroscopic methods. Dihydroxerulin (1) in admixture with xerulin (2) strongly inhibits the incorporation of 14C- acetate into cholesterol in HeLa cells while the incorporation of 14C-mevalonate is not affected. Xerulinic acid (3) shows similar biological activities but a higher cytotoxicity.
从黑绒干蘑培养物中分离出三种新的胆固醇生物合成抑制剂，并通过光谱法阐明了它们的结构。双氢绒菌素（1）与绒菌素（2）的混合物强烈抑制HeLa细胞中14C-乙酸盐掺入胆固醇，而14C-甲羟戊酸的掺入不受影响。绒菌酸（3）表现出类似的生物活性，但细胞毒性更高。
