筛选对ras癌基因表达细胞具有优先活性的抗生素。
Screening of antibiotics preferentially active against ras oncogene-expressed cells.
作者信息
Suzukake-Tsuchiya K, Moriya Y, Yamazaki K, Hori M, Hosokawa N, Sawa T, Iinuma H, Naganawa H, Imada C, Hamada M
机构信息
Showa College of Pharmaceutical Sciences, Machida city, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1990 Nov;43(11):1489-96. doi: 10.7164/antibiotics.43.1489.
During the course of in vitro screening of agents which are preferentially active against ras oncogene-expressed cells, a new anthracycline (identified as 2-demethylsteffimycin D) and a heptaene (possibly a new member of partricins) were isolated from microbial fermentation broths. Among known compounds tested, 5-fluorouracil, 5-fluorodeoxyuridine and oxanosine showed high selectivity towards ras oncogene-expressed cells.
在对优先作用于表达ras癌基因的细胞的药物进行体外筛选过程中，从微生物发酵液中分离出一种新的蒽环类抗生素（鉴定为2-去甲基司替米星D）和一种七烯类化合物（可能是盘尼西林类的新成员）。在所测试的已知化合物中，5-氟尿嘧啶、5-氟脱氧尿苷和氧杂核苷对表达ras癌基因的细胞表现出高选择性。
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