• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Treatment of dry age-related macular degeneration with dobesilate.羟苯磺酸钙治疗干性年龄相关性黄斑变性
BMJ Case Rep. 2012 Jun 21;2012:bcr0220125942. doi: 10.1136/bcr.02.2012.5942.
2
Intravitreal dobesilate in the treatment of choroidal neovascularisation associated with age-related macular degeneration: report of two cases.玻璃体内注射羟苯磺酸钙治疗年龄相关性黄斑变性伴脉络膜新生血管：两例报告
BMJ Case Rep. 2012 Sep 3;2012:bcr2012006619. doi: 10.1136/bcr-2012-006619.
3
Chronic cystoid macular oedema treated with intravitreal dobesilate.玻璃体内注射羟苯磺酸钙治疗慢性黄斑囊样水肿
BMJ Case Rep. 2012 Jul 9;2012:bcr2012006376. doi: 10.1136/bcr-2012-006376.
4
Short-term efficacy of intravitreal dobesilate in central serous chorioretinopathy.玻璃体内多贝斯治疗中心性浆液性脉络膜视网膜病变的短期疗效。
Eur J Med Res. 2012 Jul 12;17(1):22. doi: 10.1186/2047-783X-17-22.
5
Treatment of Stargardt disease with dobesilate.羟苯磺酸钙治疗斯塔加特病
BMJ Case Rep. 2012 Oct 12;2012:bcr2012007128. doi: 10.1136/bcr-2012-007128.
6
Durable recovery of the macular architecture and functionality of a diagnosed age-related macular degeneration 1 year after a single intravitreal injection of dobesilate.单次玻璃体内注射羟苯磺酸钙1年后，确诊的年龄相关性黄斑变性患者黄斑结构和功能的持久恢复。
BMJ Case Rep. 2013 Nov 13;2013:bcr2013010203. doi: 10.1136/bcr-2013-010203.
7
Intravitreal ranibizumab and bevacizumab therapy for choroidal neovascularization in age-related macular degeneration with extensive pre-existing geographic atrophy.玻璃体内注射雷珠单抗和贝伐单抗治疗年龄相关性黄斑变性伴广泛预先存在的地图样萎缩的脉络膜新生血管。
Arq Bras Oftalmol. 2012 Jul-Aug;75(4):273-6. doi: 10.1590/s0004-27492012000400011.
8
Effect of grape seed proanthocyanidin extract on hard exudates in patients with non-proliferative diabetic retinopathy.葡萄籽原花青素提取物对非增殖性糖尿病视网膜病变患者硬性渗出物的影响。
Medicine (Baltimore). 2019 May;98(21):e15515. doi: 10.1097/MD.0000000000015515.
9
Outer retinal corrugations in age-related macular degeneration.年龄相关性黄斑变性中的外层视网膜皱褶
JAMA Ophthalmol. 2014 Jul;132(7):806-13. doi: 10.1001/jamaophthalmol.2014.1871.
10
Microperimetry Features of Geographic Atrophy Identified With En Face Optical Coherence Tomography.经表面光学相干断层扫描识别的地图样萎缩的微视野特征
JAMA Ophthalmol. 2016 Aug 1;134(8):873-9. doi: 10.1001/jamaophthalmol.2016.1535.

引用本文的文献

1
Anti-Angiogenic and Anti-Scarring Dual Action of an Anti-Fibroblast Growth Factor 2 Aptamer in Animal Models of Retinal Disease.抗成纤维细胞生长因子2适体在视网膜疾病动物模型中的抗血管生成和抗瘢痕双重作用
Mol Ther Nucleic Acids. 2019 Sep 6;17:819-828. doi: 10.1016/j.omtn.2019.07.018. Epub 2019 Aug 1.
2
Diacetyloxyl derivatization of the fibroblast growth factor inhibitor dobesilate enhances its anti-inflammatory, anti-angiogenic and anti-tumoral activities.成纤维细胞生长因子抑制剂羟苯磺酸的二乙酰氧基衍生化增强了其抗炎、抗血管生成和抗肿瘤活性。
J Transl Med. 2015 Feb 1;13:48. doi: 10.1186/s12967-015-0413-4.
3
Treatment of Stargardt disease with dobesilate.羟苯磺酸钙治疗斯塔加特病
BMJ Case Rep. 2012 Oct 12;2012:bcr2012007128. doi: 10.1136/bcr-2012-007128.
4
Intravitreal dobesilate in the treatment of choroidal neovascularisation associated with age-related macular degeneration: report of two cases.玻璃体内注射羟苯磺酸钙治疗年龄相关性黄斑变性伴脉络膜新生血管：两例报告
BMJ Case Rep. 2012 Sep 3;2012:bcr2012006619. doi: 10.1136/bcr-2012-006619.
5
Chronic cystoid macular oedema treated with intravitreal dobesilate.玻璃体内注射羟苯磺酸钙治疗慢性黄斑囊样水肿
BMJ Case Rep. 2012 Jul 9;2012:bcr2012006376. doi: 10.1136/bcr-2012-006376.

本文引用的文献

1
Microglia in the outer retina and their relevance to pathogenesis of age-related macular degeneration.外视网膜中的小胶质细胞及其与年龄相关性黄斑变性发病机制的关系。
Adv Exp Med Biol. 2012;723:37-42. doi: 10.1007/978-1-4614-0631-0_6.
2
Acidic fibroblast growth factor (FGF) potentiates glial-mediated neurotoxicity by activating FGFR2 IIIb protein.酸性成纤维细胞生长因子（FGF）通过激活 FGFR2 IIIb 蛋白增强神经胶质介导的神经毒性。
J Biol Chem. 2011 Dec 2;286(48):41230-41245. doi: 10.1074/jbc.M111.270470. Epub 2011 Oct 11.
3
Age related macular degeneration and drusen: neuroinflammation in the retina.年龄相关性黄斑变性和玻璃膜疣：视网膜中的神经炎症。
Prog Neurobiol. 2011 Sep 15;95(1):14-25. doi: 10.1016/j.pneurobio.2011.05.011. Epub 2011 Jun 28.
4
Inflammation and age-related macular degeneration (AMD).炎症与年龄相关性黄斑变性（AMD）
Semin Ophthalmol. 2011 May;26(3):192-7. doi: 10.3109/08820538.2011.570849.
5
Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors.龙胆酸是一种与植物防御有关的化合物，也是阿司匹林的一种代谢物，它是一类新型的体内成纤维细胞生长因子抑制剂。
J Biol Chem. 2010 Apr 9;285(15):11714-29. doi: 10.1074/jbc.M109.064618. Epub 2010 Feb 9.
6
Correlation between spectral-domain optical coherence tomography and fundus autofluorescence at the margins of geographic atrophy.地理性萎缩边缘处的频域光学相干断层扫描与眼底自发荧光之间的相关性
Am J Ophthalmol. 2009 Sep;148(3):439-44. doi: 10.1016/j.ajo.2009.04.022. Epub 2009 Jul 9.
7
Effect of calcium dobesilate on occurrence of diabetic macular oedema (CALDIRET study): randomised, double-blind, placebo-controlled, multicentre trial.羟苯磺酸钙对糖尿病性黄斑水肿发生的影响（CALDIRET研究）：随机、双盲、安慰剂对照、多中心试验
Lancet. 2009 Apr 18;373(9672):1364-71. doi: 10.1016/S0140-6736(09)60218-X.
8
Amyloid-beta up-regulates complement factor B in retinal pigment epithelial cells through cytokines released from recruited macrophages/microglia: Another mechanism of complement activation in age-related macular degeneration.淀粉样β蛋白通过募集的巨噬细胞/小胶质细胞释放的细胞因子上调视网膜色素上皮细胞中的补体因子B：年龄相关性黄斑变性中补体激活的另一种机制。
J Cell Physiol. 2009 Jul;220(1):119-28. doi: 10.1002/jcp.21742.
9
Ex vivo dynamic imaging of retinal microglia using time-lapse confocal microscopy.使用延时共聚焦显微镜对视网膜小胶质细胞进行离体动态成像。
Invest Ophthalmol Vis Sci. 2008 Sep;49(9):4169-76. doi: 10.1167/iovs.08-2076. Epub 2008 May 16.
10
High-resolution spectral domain-OCT imaging in geographic atrophy associated with age-related macular degeneration.高分辨率光谱域光学相干断层扫描成像在与年龄相关性黄斑变性相关的地图样萎缩中的应用
Invest Ophthalmol Vis Sci. 2008 Sep;49(9):4137-44. doi: 10.1167/iovs.08-1967. Epub 2008 May 16.

羟苯磺酸钙治疗干性年龄相关性黄斑变性

Treatment of dry age-related macular degeneration with dobesilate.

作者信息

Cuevas P, Outeiriño L A, Angulo J, Giménez-Gallego G

机构信息

Departamento de Investigación, IRYCIS, Hospital Universitario Ramón y Cajal, Madrid, Spain.

出版信息

BMJ Case Rep. 2012 Jun 21;2012:bcr0220125942. doi: 10.1136/bcr.02.2012.5942.

DOI:10.1136/bcr.02.2012.5942
PMID:22729337
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3387461/
Abstract

The authors present anatomical and functional evidences of dry age-macular degeneration improvement, after intravitreal treatment with dobesilate. Main outcomes measures were normalisation of retinal structure and function, assessed by optical coherence tomography, fundus-monitored microperimetry, electrophysiology and visual acuity. The effect might be related to the normalisation of the outer retinal architecture.

摘要

作者展示了在用羟苯磺酸进行玻璃体内治疗后干性年龄相关性黄斑变性改善的解剖学和功能证据。主要结局指标是通过光学相干断层扫描、眼底监测微视野检查、电生理学和视力评估视网膜结构和功能的正常化。这种效果可能与视网膜外层结构的正常化有关。