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单次玻璃体内注射羟苯磺酸钙1年后，确诊的年龄相关性黄斑变性患者黄斑结构和功能的持久恢复。

Durable recovery of the macular architecture and functionality of a diagnosed age-related macular degeneration 1 year after a single intravitreal injection of dobesilate.

作者信息

Cuevas P, Outeiriño L A, Azanza C, Giménez-Gallego G

机构信息

Departamento de Investigación, IRYCIS, Hospital Universitario Ramón y Cajal, Madrid, Spain.

出版信息

BMJ Case Rep. 2013 Nov 13;2013:bcr2013010203. doi: 10.1136/bcr-2013-010203.

DOI:10.1136/bcr-2013-010203
PMID:24225910
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3830417/
Abstract

Among the age-related diseases that affect vision, age-related macular degeneration is the most frequent cause of blindness in patients older than 60 years. In this communication, we report the full anatomical and functional recovery of a patient diagnosed with wet age-related macular degeneration 1 year after a single intravitreal injection of dobesilate.

摘要

在影响视力的与年龄相关的疾病中，年龄相关性黄斑变性是60岁以上患者失明的最常见原因。在本报告中，我们报道了一名被诊断为湿性年龄相关性黄斑变性的患者在单次玻璃体内注射羟苯磺酸钙1年后实现了完全的解剖和功能恢复。

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Durable recovery of the macular architecture and functionality of a diagnosed age-related macular degeneration 1 year after a single intravitreal injection of dobesilate.单次玻璃体内注射羟苯磺酸钙1年后，确诊的年龄相关性黄斑变性患者黄斑结构和功能的持久恢复。
BMJ Case Rep. 2013 Nov 13;2013:bcr2013010203. doi: 10.1136/bcr-2013-010203.
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本文引用的文献

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Altered cytokine profiles of human retinal pigment epithelium: oxidant injury and replicative senescence.人视网膜色素上皮细胞细胞因子谱的改变：氧化损伤与复制性衰老。
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Targeted deletion of Vegfa in adult mice induces vision loss.在成年小鼠中靶向性删除 Vegfa 会导致视力丧失。
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Clinical and differential utility of VEGF inhibitors in wet age-related macular degeneration: focus on aflibercept.血管内皮生长因子抑制剂在湿性年龄相关性黄斑变性中的临床及鉴别诊断效用：聚焦于阿柏西普
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Intravitreal dobesilate in the treatment of choroidal neovascularisation associated with age-related macular degeneration: report of two cases.玻璃体内注射羟苯磺酸钙治疗年龄相关性黄斑变性伴脉络膜新生血管：两例报告
BMJ Case Rep. 2012 Sep 3;2012:bcr2012006619. doi: 10.1136/bcr-2012-006619.
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Topical treatment of contact dermatitis by pine processionary caterpillar.松毒蛾对接触性皮炎的局部治疗
BMJ Case Rep. 2011 Aug 11;2011:bcr0620114351. doi: 10.1136/bcr.06.2011.4351.
6
Long-term effectiveness of dobesilate in the treatment of papulopustular rosacea.羟苯磺酸钙治疗丘疹脓疱型玫瑰痤疮的长期疗效
BMJ Case Rep. 2011 Oct 16;2011:bcr0820114579. doi: 10.1136/bcr.08.2011.4579.
7
Inhibition of vascular endothelial growth factor (VEGF)-induced endothelial proliferation, arterial relaxation, vascular permeability and angiogenesis by dobesilate.羟苯磺酸钙抑制血管内皮生长因子（VEGF）诱导的内皮细胞增殖、动脉舒张、血管通透性和血管生成。
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8
Age-related macular degeneration (AMD): Alzheimer's disease in the eye?年龄相关性黄斑变性（AMD）：眼睛里的阿尔茨海默病？
J Alzheimers Dis. 2011;24(4):615-31. doi: 10.3233/JAD-2011-101908.
9
Gentisic acid, a compound associated with plant defense and a metabolite of aspirin, heads a new class of in vivo fibroblast growth factor inhibitors.龙胆酸是一种与植物防御有关的化合物，也是阿司匹林的一种代谢物，它是一类新型的体内成纤维细胞生长因子抑制剂。
J Biol Chem. 2010 Apr 9;285(15):11714-29. doi: 10.1074/jbc.M109.064618. Epub 2010 Feb 9.
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Soluble and mature amyloid fibrils in drusen deposits.在玻璃膜疣沉积物中可溶解的和成熟的淀粉样纤维。
Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1304-10. doi: 10.1167/iovs.09-4207. Epub 2009 Nov 5.