Emerging Infectious Diseases Program, Duke-NUS Graduate Medical School, Singapore, Republic of Singapore.
Arch Virol. 2012 Oct;157(10):1989-93. doi: 10.1007/s00705-012-1388-6. Epub 2012 Jun 23.
Salem virus (SalPV) was originally isolated from a horse during a disease outbreak in 1992 in the USA. In this study, we complete the genome characterization of SalPV and confirm the classification of this virus as a member of the subfamily Paramyxovirinae. The SalPV genome is 16,698 nucleotides in length, with six transcriptional units in the order 3'-N/P/V/C-M-F-G-L-5'. SalPV has a fixed 3-nt intergenic region, which is the same as in all Paramyxovirinae members except rubulaviruses and avulaviruses. The genome size of SalPV is greater than those of the "old" members of the subfamily, such as morbilliviruses and respiroviruses, but smaller than those of the "new" members, including henipaviruses and several unclassified novel viruses. Interestingly, this evolutionary "middle point" was also reflected in the phylogeny, suggesting that SalPV represents an important intermediate between the previously well-characterized paramyxoviruses and the recently emerged members of this subfamily.
萨利姆病毒（SalPV）最初是在 1992 年美国的一次疾病爆发中从一匹马身上分离出来的。在这项研究中，我们完成了 SalPV 的基因组特征描述，并证实该病毒被分类为副粘病毒亚科的成员。SalPV 基因组全长 16698 个核苷酸，有六个转录单元，顺序为 3'-N/P/V/C-M-F-G-L-5'。SalPV 具有固定的 3 个核苷酸的基因间区，与除了 rubulaviruses 和 avulaviruses 之外的所有副粘病毒亚科成员相同。SalPV 的基因组大小大于该亚科的“旧”成员，如麻疹病毒和呼吸病毒，但小于“新”成员，包括亨德拉病毒和几种未分类的新病毒。有趣的是，这种进化的“中间点”也反映在系统发育中，表明 SalPV 代表了先前充分描述的副粘病毒和该亚科最近出现的成员之间的重要中间环节。
