Miller Philippa J, Boyle David B, Eaton Bryan T, Wang Lin-Fa
CSIRO Livestock Industries, Australian Animal Health Laboratory, Private Bag 24, Geelong, Victoria 3220, Australia.
Virology. 2003 Dec 20;317(2):330-44. doi: 10.1016/j.virol.2003.08.013.
Mossman virus (MoV) was isolated on two occasions from wild rats trapped in Queensland, Australia, during the early 1970s. Together with Nariva virus and J-virus MoV belongs to a group of novel paramyxoviruses isolated from rodents during the last 40 years, none of which had been characterized at the molecular level until now. cDNA subtraction strategies used to isolate virus-specific cDNA derived from both MoV-infected cells and crude MoV pellets were pivotal steps in rapid characterization of the complete genome sequence. Analysis of the full-length genome and its encoded proteins confirmed that MoV is a novel member of the subfamily Paramyxovirinae which cannot be assigned to an existing genus. MoV appears to be more closely related to another unclassified paramyxovirus Tupaia paramyxovirus (TPMV), isolated from the tree shrew Tupaia belangeri. Together with Salem virus (SalV), a further unclassified paramyxovirus that was isolated from a horse, MoV and TPMV make up a new collection of paramyxoviruses situated evolutionally between the genus Morbillivirus and the newly established genus Henipavirus.
莫斯曼病毒（MoV）于20世纪70年代初在澳大利亚昆士兰州捕获的野生大鼠中被分离出两次。与纳里瓦病毒和J病毒一样，MoV属于过去40年中从啮齿动物中分离出的一组新型副粘病毒，直到现在，这些病毒都没有在分子水平上得到表征。用于从MoV感染细胞和粗制MoV沉淀中分离病毒特异性cDNA的cDNA扣除策略是快速确定完整基因组序列的关键步骤。对全长基因组及其编码蛋白的分析证实，MoV是副粘病毒亚科的一个新成员，无法归入现有的属。MoV似乎与另一种未分类的副粘病毒——从树鼩（Tupaia belangeri）中分离出的树鼩副粘病毒（TPMV）关系更密切。与从一匹马中分离出的另一种未分类的副粘病毒——塞勒姆病毒（SalV）一起，MoV和TPMV构成了一组新的副粘病毒，在进化上位于麻疹病毒属和新建立的亨尼帕病毒属之间。
