Cardiovascular Research Unit, Department of Medical Sciences, Centre for Clinical and Basic Research, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele Pisana, via della Pisana 235, 00163 Rome, Italy.
Endocrine. 2012 Oct;42(2):272-7. doi: 10.1007/s12020-012-9725-9. Epub 2012 Jun 24.
Testosterone deficiency is a generalized phenomenon seen in the course of chronic heart failure (CHF). Reduction in circulating testosterone level is a predictor of deterioration of functional capacity over time, underscoring the role of testosterone deficiency in CHF. Anabolic hormones are determinants of exercise capacity and circulating levels of anabolic hormones strongly determine muscle mass and strength. Testosterone deficiency is involved in the pathophysiology of CHF, contributing to some features of this syndrome, such as the reduced muscle mass, abnormal energy handling, fatigue, dyspnea and, finally, cachexia. This review summarizes current knowledge on the role of testosterone deficiency in the pathophysiology of CHF, gaining insights from the potential implications of testosterone as supplementation therapy.
睾酮缺乏是慢性心力衰竭（CHF）过程中普遍存在的现象。循环睾酮水平降低是随着时间推移功能能力恶化的预测指标，强调了睾酮缺乏在 CHF 中的作用。合成代谢激素是运动能力的决定因素，循环合成代谢激素水平强烈决定肌肉质量和力量。睾酮缺乏与 CHF 的病理生理学有关，导致该综合征的一些特征，如肌肉质量减少、能量处理异常、疲劳、呼吸困难，最终导致恶病质。本综述总结了目前关于睾酮缺乏在 CHF 病理生理学中的作用的知识，从睾酮作为补充治疗的潜在影响中获得了一些见解。
