Chen Lei, Liu Bilin, Qin Yuan, Li Anqi, Gao Meng, Liu Hanyu, Gong Guohua
Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Department of Pharmacy, Shanghai East Hospital, Tongji University, Shanghai, China.
Front Mol Biosci. 2021 May 7;8:681237. doi: 10.3389/fmolb.2021.681237. eCollection 2021.
Mitofusin 2 (Mfn2) is a transmembrane GTPase located on the mitochondrial outer membrane that contributes to mitochondrial network regulation. It is an essential multifunctional protein that participates in various biological processes under physical and pathological conditions, including mitochondrial fusion, reticulum-mitochondria contacts, mitochondrial quality control, and apoptosis. Mfn2 dysfunctions have been found to contribute to cardiovascular diseases, such as ischemia-reperfusion injury, heart failure, and dilated cardiomyopathy. Here, this review mainly focuses on what is known about the structure and function of Mfn2 and its crucial role in heart failure.
线粒体融合蛋白2（Mfn2）是一种位于线粒体外膜的跨膜GTP酶，有助于线粒体网络的调控。它是一种必需的多功能蛋白，在生理和病理条件下参与各种生物学过程，包括线粒体融合、内质网-线粒体接触、线粒体质量控制和细胞凋亡。已发现Mfn2功能障碍与心血管疾病有关，如缺血-再灌注损伤、心力衰竭和扩张型心肌病。本文综述主要聚焦于Mfn2的结构与功能以及其在心力衰竭中的关键作用。
