Zhu Tie-Nan, Zhao Yong-Qiang, Ding Qiu-Lan, Bai Xia, Wang Xiao-Yan, Wang Xue-Feng, Yang Ren-Chi, Wang Zhao-Yue, Hua Bao-Lai, Wel Xu-Qian, Ruan Chang-Geng, Schlegel Nicole
Department of Hematology, Peking Union Medical College Hospital, CAMS, Beijing 100730, China.
Zhonghua Xue Ye Xue Za Zhi. 2012 Feb;33(2):127-30.
To explore the distribution and influence factors of protein C (PC), protein S (PS) and antithrombin (AT) activities and to determine the prevalence of their deficiencies in the Chinese Han healthy population.
Healthy volunteers including blood donors and individuals for routine check-up were recruited from 4 Chinese medical centers. The plasma levels of PC, PS and AT activities were measured. The plasma levels of activities were measured by chromogenic substrate assay (AT and PC) and clotting assay (PS).
A total of 3493 healthy Chinese adults had been recruited in this study. Males had higher PS and PC activities than females, especially for PS (P < 0.01). PC activities increased with age in both sexes but decreased in men after 50 years old. There was no significant change with age were of PS in 50 years old, while there was a decline in males and a rise in females above 50 years old. AT tended to increase with age in women but decreased with age in men after 50 years old. Based on the age and gender, the general prevalence of PC, PS and AT deficiencies in the general Chinese Han population were 1.15%, 1.49% and 2.29%, respectively.
PC, PS and AT activities have correlation with age and gender in Chinese Han population. Reference range should be laid down and deficiencies should be identified
探讨蛋白C（PC）、蛋白S（PS）和抗凝血酶（AT）活性的分布及影响因素，确定中国汉族健康人群中这些蛋白缺乏的发生率。
从4家中国医疗中心招募包括献血者和进行常规体检者在内的健康志愿者。检测血浆中PC、PS和AT的活性水平。活性水平采用发色底物法（检测AT和PC）和凝血法（检测PS）进行测定。
本研究共招募了3493名中国健康成年人。男性的PS和PC活性高于女性，尤其是PS（P<0.01）。PC活性在两性中均随年龄增长而升高，但男性在50岁后下降。50岁时PS活性随年龄无显著变化，而50岁以上男性下降，女性上升。女性中AT随年龄增长有升高趋势，而男性在50岁后随年龄下降。基于年龄和性别，中国汉族人群中PC、PS和AT缺乏的总体发生率分别为1.15%、1.49%和2.29%。
中国汉族人群中PC、PS和AT活性与年龄和性别相关。应制定参考范围并识别缺乏情况。
