Institut Pasteur, Unité de Génétique des Biofilms, Département de Microbiologie, 25-28 rue du Dr Roux, F-75015 Paris, France.
Environ Microbiol. 2013 Feb;15(2):334-46. doi: 10.1111/j.1462-2920.2012.02810.x. Epub 2012 Jun 26.
Bacterial extracellular polysaccharides have been shown to mediate many of the cell-to-cell and cell-to-surface interactions that are required for the formation, cohesion and stabilization of bacterial biofilms. However, recent studies have identified several bacterial polysaccharides that inhibit biofilm formation by a wide spectrum of bacteria and fungi both in vitro and in vivo. This review discusses the composition, modes of action and potential biological roles of antibiofilm polysaccharides recently identified in bacteria and eukarya. Some of these molecules may have technological applications as antibiofilm agents in industry and medicine.
细菌胞外多糖已被证明介导了许多细胞间和细胞与表面的相互作用，这些相互作用对于细菌生物膜的形成、凝聚和稳定是必需的。然而，最近的研究已经确定了几种细菌多糖，它们在体外和体内抑制了广泛的细菌和真菌的生物膜形成。本文讨论了最近在细菌和真核生物中发现的抗生物膜多糖的组成、作用模式和潜在生物学作用。这些分子中的一些可能具有作为工业和医学中抗生物膜剂的技术应用。
