Department of Geriatric Medicine, Odense University Hospital, DK-5000, Odense C, Denmark.
BMC Geriatr. 2012 Jun 25;12:32. doi: 10.1186/1471-2318-12-32.
Functional decline is associated with increased risk of mortality in geriatric patients. Assessment of activities of daily living (ADL) with the Barthel Index (BI) at admission was studied as a predictor of survival in older patients admitted to an acute geriatric unit.
All first admissions of patients with age >65 years between January 1st 2005 and December 31st 2009 were included. Data on BI, sex, age, and discharge diagnoses were retrieved from the hospital patient administrative system, and data on survival until September 6th 2010 were retrieved from the Civil Personal Registry. Co-morbidity was measured with Charlson Co-morbidity Index (CCI). Patients were followed until death or end of study.
5,087 patients were included, 1,852 (36.4%) men and 3,235 (63.6%) women with mean age 81.8 (6.8) and 83.9 (7.0) years respectively. The median [IQR] length of stay was 8 days, the median follow up [IQR] 1.4 [0.3; 2.8] years and in hospital mortality 8.2%. Mortality was greater in men than in women with median survival (95%-CI) 1.3 (1.2 -1.5) years and 2.2 (2.1-2.4) years respectively (p < 0.001). The median survivals (95%-CI) stratified on BI groups in men (n = 1,653) and women (n = 2,874) respectively were: BI 80-100: 2.6 (1.9-3.1) years and 4.5 (3.9-5.4) years; BI 50-79: 1.7 (1.5-2.1) years and 3.1 (2.7-3.5) years; BI 25-49: 1.5 (1.3-1.9) years and 1.9 (1.5-2.2) years and BI 0-24: 0.5 (0.3-0.7) years and 0.8 (0.6-0.9) years. In multivariate logistic regression analysis with BI 80-100 as baseline and controlling for significant covariates (sex, age, CCI, and diseases of cancer, haematology, cardiovascular, respiratory, infectious and bone and connective tissues) the odds ratios for 3 and 12 months survival (95%-CI) decreased with declining BI: BI 50-79: 0.74 (0.55-0.99) (p < 0.05) and 0,80 (0.65-0.97)(p < 0.05); BI 25-49: 0.44 (0.33-0.59)(p < 0.001) and 0.55 (0.45-0.68)(p < 0.001); and BI 0-24: 0.18 (0.14-0.24)(p < 0.001) and 0.29 (0.24-0.35)(p < 0.001) respectively.
BI is a strong independent predictor of survival in older patients admitted to an acute geriatric unit. These data suggest that assessment of ADL may have a potential role in decision making for the clinical management of frail geriatric inpatients.
功能下降与老年患者的死亡率增加有关。本研究旨在评估入院时日常生活活动能力(ADL)的巴氏量表(BI)评分,作为预测老年患者入住急性老年病房后生存状况的指标。
纳入 2005 年 1 月 1 日至 2009 年 12 月 31 日期间首次入住年龄>65 岁的患者。从医院患者管理系统中检索 BI、性别、年龄和出院诊断的数据,并从公民个人登记处检索截至 2010 年 9 月 6 日的生存数据。共病采用 Charlson 共病指数(CCI)进行评估。患者在死亡或研究结束前接受随访。
共纳入 5087 例患者,其中男性 1852 例(36.4%),女性 3235 例(63.6%),平均年龄分别为 81.8(6.8)岁和 83.9(7.0)岁。中位[IQR]住院时间为 8 天,中位[IQR]随访时间为 1.4[0.3;2.8]年,院内死亡率为 8.2%。男性死亡率高于女性,中位生存时间(95%CI)分别为 1.3(1.2-1.5)年和 2.2(2.1-2.4)年(p<0.001)。男性(n=1653)和女性(n=2874)BI 组的中位生存时间(95%CI)分别为:BI 80-100:2.6(1.9-3.1)年和 4.5(3.9-5.4)年;BI 50-79:1.7(1.5-2.1)年和 3.1(2.7-3.5)年;BI 25-49:1.5(1.3-1.9)年和 1.9(1.5-2.2)年;BI 0-24:0.5(0.3-0.7)年和 0.8(0.6-0.9)年。在以 BI 80-100 为基线,控制性别、年龄、CCI 和癌症、血液学、心血管、呼吸、感染和骨骼及结缔组织疾病等显著协变量的多变量逻辑回归分析中,3 个月和 12 个月生存的优势比(95%CI)随着 BI 的下降而降低:BI 50-79:0.74(0.55-0.99)(p<0.05)和 0.80(0.65-0.97)(p<0.05);BI 25-49:0.44(0.33-0.59)(p<0.001)和 0.55(0.45-0.68)(p<0.001);BI 0-24:0.18(0.14-0.24)(p<0.001)和 0.29(0.24-0.35)(p<0.001)。
BI 是预测老年患者入住急性老年病房后生存状况的有力独立预测指标。这些数据表明,ADL 的评估可能在脆弱老年住院患者的临床管理决策中具有潜在作用。