[Protein synthesis in a hepatocyte culture in the presence of exogenous adenylic and guanyl nucleotides].

Circahoral opposite-in phase fluctuations of protein syntheses and intracellular ATP content have been observed in monolayer hepatocyte cell culture. Peculiarities of protein synthesis in hepatocytes have been studied in vitro in presence of adenylic and guanylic nucleotides. Addition of exogenous ATP leads to the decrease in the level of protein synthesis and smoothing off of the fluctuations. The presence of exogenous ADP leads to the increase in protein synthesis and retaining of the amplitude of fluctuations of this process. Effect of exogenous GTP is similar to that of ATP. Different aspects of action of exogenous NTPs on the rhythms of protein synthesis have been considered.