Lobo Suzana Margareth
Crit Care. 2012 Jun 18;16(3):130. doi: 10.1186/CC11347.
C-reactive protein (CRP) is a marker of inflammation traditionally used as a complementary tool to support the clinical diagnosis and as a marker of severity of disease. CRP is an acute-phase protein synthesized by the liver after stimulus by cytokines and its serum levels increase markedly within hours after the onset of infection, inflammation or tissue injury. Dynamic serial measurement of CRP has been widely used to help therapeutic decision-making. Decreasing plasma concentrations of this biomarker have been used as an indicator for resolution of infection or sepsis.
C反应蛋白(CRP)是一种炎症标志物,传统上用作辅助临床诊断的工具以及疾病严重程度的标志物。CRP是一种急性期蛋白,由肝脏在细胞因子刺激后合成,其血清水平在感染、炎症或组织损伤发作后的数小时内显著升高。CRP的动态连续测量已被广泛用于辅助治疗决策。这种生物标志物血浆浓度的下降已被用作感染或脓毒症消退的指标。