Department of Environmental Health Sciences, University at Albany, State University of New York, Rensselaer, NY, USA.
Reprod Toxicol. 2012 Nov;34(3):471-81. doi: 10.1016/j.reprotox.2012.06.002. Epub 2012 Jun 23.
Low-level environmental exposure to Hg, Pb and Cd may interfere with pregnancy during in vitro fertilization (IVF). The aim of this study was to generate hypotheses concerning associations between background exposures and pregnancy. In modified Poisson regression models including 24 women and adjusted for urine Cd and creatinine, blood Pb, age, race and smoking, 1 μg/L increases in blood Hg are associated with decreases of 35% (P=0.03) and 33% (P=0.01) in clinical and biochemical pregnancies, respectively. In alternate Poisson models including 26 women and adjusted for blood Pb, blood Hg, age, race and smoking, 1 μg/L increases in blood Cd are associated with decreases of 94% (P=0.01) and 82% (P=0.04) in clinical and biochemical pregnancies, respectively. No effects are detected in 15 men, although inverse associations are suggested for urine cadmium and pregnancy. These data suggest that low-level, background exposures to Hg and Cd may interfere with pregnancy following IVF.
低水平环境汞、铅和镉暴露可能会干扰体外受精（IVF）期间的妊娠。本研究的目的是提出与背景暴露相关的假设。在包括 24 名女性的修正泊松回归模型中，根据尿镉和肌酐、血铅、年龄、种族和吸烟情况进行调整，血汞每增加 1μg/L，临床妊娠和生化妊娠分别下降 35%（P=0.03）和 33%（P=0.01）。在包括 26 名女性的替代泊松模型中，根据血铅、血汞、年龄、种族和吸烟情况进行调整，血镉每增加 1μg/L，临床妊娠和生化妊娠分别下降 94%（P=0.01）和 82%（P=0.04）。15 名男性未检测到效果，尽管尿液中镉与妊娠呈负相关。这些数据表明，低水平的背景汞和镉暴露可能会干扰 IVF 后的妊娠。
