Department of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada.
Acta Biomater. 2012 Oct;8(10):3596-605. doi: 10.1016/j.actbio.2012.06.013. Epub 2012 Jun 23.
Nanogels based on poly(N-isopropylacrylamide) are attractive vehicles for prolonged duration local anesthesia because of their tunable size, number of functional groups, thermoresponsiveness and anionic charge. Nerve block durations of up to 9h were achieved using acrylic acid-loaded nanogels loaded with bupivacaine. Increasing the anionic charge density of the nanogels or (for more highly acid-functionalized nanogels) decreasing the nanogel size facilitated longer duration of anesthetic release. Small (<300 nm diameter) nanogels formed dense aggregates upon injection in vivo and induced only mild inflammatory responses, while large (>500 nm diameter) nanogels typically remained as liquid-like residues in vivo and induced more severe inflammatory reactions.
基于聚（N-异丙基丙烯酰胺）的纳米凝胶因其可调的尺寸、官能团数量、温度响应性和阴离子电荷而成为延长局部麻醉持续时间的有吸引力的载体。用载有布比卡因的丙烯酸负载的纳米凝胶实现了长达 9 小时的神经阻滞持续时间。增加纳米凝胶的阴离子电荷密度或（对于具有更高酸官能化的纳米凝胶）减小纳米凝胶的尺寸，有助于延长麻醉释放的持续时间。小（<300nm 直径）纳米凝胶在体内注射时形成致密的聚集体，仅引起轻微的炎症反应，而大（>500nm 直径）纳米凝胶通常在体内保持液态残留，并引起更严重的炎症反应。
