Gupta Jitendra, Sharma Gaurang
Institute of Pharmaceutical Research, GLA University, Mathura, 281406, Uttar Pradesh, India.
Drug Deliv Transl Res. 2025 Feb;15(2):455-482. doi: 10.1007/s13346-024-01684-w. Epub 2024 Aug 5.
Nanogel (NG) drug delivery systems have emerged as promising tools for targeted and controlled drug release, revolutionizing treatment approaches across various diseases. Their unique physicochemical properties, such as nano size, high surface area, biocompatibility, stability, and tunable drug release, make them ideal carriers for a wide range of therapeutic agents. Nanogels (NGs), characterized by their 3D network of crosslinked polymers, offer unique edges like high drug loading capacity, controlled release, and targeted delivery. Additionally, the diverse applications of NGs in medical therapeutics highlight their versatility and potential impact on improving patient outcomes. Their application spans cancer treatment, infectious diseases, and chronic conditions, allowing for precise drug delivery to specific tissues or cells, minimizing side effects, and enhancing therapeutic efficacy. Despite their potential, challenges such as scalability, manufacturing reproducibility, and regulatory hurdles must be addressed. Achieving clinical translation requires overcoming these obstacles to ensure therapeutic payloads' safe and efficient delivery. Strategies such as surface modification and incorporating stimuli-responsive elements enhanced NG performance and addressed specific therapeutic challenges. Advances in nanotechnology, biomaterials, and targeted drug design offer opportunities to improve the performance of NGs and address current limitations. Tailoring NGs for exploring combination therapies and integrating diagnostics for real-time monitoring represent promising avenues for future research. In conclusion, NG drug delivery systems have demonstrated tremendous potential in diverse disease applications. Overcoming challenges and leveraging emerging technologies will pave the way for their widespread clinical implementation, ushering in a new era of precision medicine and improved patient care.
纳米凝胶（NG）给药系统已成为靶向和控释药物的有前途的工具，彻底改变了各种疾病的治疗方法。它们独特的物理化学性质，如纳米尺寸、高表面积、生物相容性、稳定性和可调的药物释放，使其成为多种治疗剂的理想载体。纳米凝胶（NGs）以其交联聚合物的三维网络为特征，具有高载药量、控释和靶向递送等独特优势。此外，NGs在医学治疗中的多样应用突出了它们的多功能性以及对改善患者治疗效果的潜在影响。它们的应用涵盖癌症治疗、传染病和慢性病，能够将药物精确递送至特定组织或细胞，最大限度地减少副作用并提高治疗效果。尽管它们具有潜力，但仍需解决诸如可扩展性、制造重现性和监管障碍等挑战。实现临床转化需要克服这些障碍，以确保治疗药物的安全有效递送。诸如表面修饰和引入刺激响应元件等策略可增强NG的性能并应对特定的治疗挑战。纳米技术、生物材料和靶向药物设计的进展为改善NGs的性能和解决当前局限性提供了机会。定制NGs以探索联合疗法并整合诊断以进行实时监测是未来研究的有前景的途径。总之，NG给药系统在多种疾病应用中已展现出巨大潜力。克服挑战并利用新兴技术将为其广泛的临床应用铺平道路，开创精准医学和改善患者护理的新时代。
