Department of Biosciences, Kyushu Dental College, Kitakyushu, Japan.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Jul;114(1):17-26. doi: 10.1016/j.tripleo.2011.05.025. Epub 2011 Aug 26.
The aim of this study was to evaluate the effects of thymosin β4 (TB4) on wound healing after tooth extraction in rats.
After extraction of the rats' mandibular first molar teeth, a synthetic partial peptide of TB4 was injected intraperitoneally at the time of extraction and every day thereafter for 6 days. Control subjects for the treatment received identical amounts of phosphate-buffered saline solution in the same manner. Histologic analysis, apoptosis assay, and reverse-transcription polymerase chain reaction were performed.
The overall data showed that TB4 treatment suppressed apoptosis and inflammation; it accelerated the process of wound healing, including new bone formation.
The findings demonstrated not only the usefulness of the TB4 partial peptide in wound healing of tooth extraction sockets, but also its potential application for bone regeneration and osteogenesis in bone and bone-related tissues.
本研究旨在评估胸腺肽 β4（TB4）对大鼠拔牙后伤口愈合的影响。
在大鼠下颌第一磨牙拔牙后，在拔牙时和此后的 6 天内每天通过腹腔注射合成 TB4 部分肽。治疗组的对照受试者以相同的方式接受相同量的磷酸盐缓冲盐水溶液。进行组织学分析、细胞凋亡检测和逆转录聚合酶链反应。
总体数据表明，TB4 处理抑制了细胞凋亡和炎症；它加速了伤口愈合过程，包括新骨形成。
这些发现不仅证明了 TB4 部分肽在拔牙窝伤口愈合中的有用性，还证明了其在骨和骨相关组织中的骨再生和成骨中的潜在应用。
