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[欧洲癌症研究与治疗组织QLQ-C30问卷在预测墨西哥头颈癌患者营养不良风险中的作用]

[EORTC QLQ-C30 questionnaire role as predictor for malnutrition risk in head and neck cancer Mexican patients].

作者信息

Sat-Muñoz D, Morán Mendoza A de J, Solano-Murillo P, Balderas-Peña L M A, Rivera-Morales D, Iñíguez-Virgen A, Salcedo-Rocha A L, García de Alba-García J E

机构信息

Oncología Quirúrgica, Hospital General Regional No. 46, Instituto Mexicano del Seguro Social, México.

出版信息

Nutr Hosp. 2012 Mar-Apr;27(2):477-82. doi: 10.1590/S0212-16112012000200019.

Abstract

INTRODUCTION

Head and neck cancer treatment restricts oral intake and conditioning malnutrition. Adequate nutritional support during treatment can limit the impact of side effects.

OBJECTIVE

To describe EORTC QLQ-C30 role for malnutrition risk screening in head and neck cancer patients.

METHODS

Analytical and cross-sectional, diagnostic test study in head and neck cancer patients. We correlated malnutrition diagnosis with subjective global assessment (SGA) and score for the EORTC QLQ-C30 scales with Pearson and Spearman correlation. We realized COR (Receiver Operating Characteristic) curves to calculate cut point in the score for the EORTC QLQ-C30 scales; we calculated sensitivity, specificity, positive predictive value, negative predictive value and Odds Ratio through logistic regression.

RESULTS

Functional scales (role, physic, global health status/QoL) showed limited utility to malnutrition risk estimation in people with head and neck cancer. Symptoms' scales with strong association were: pain (sensitivity 76.47%, specificity 69.23%), insomnia (sensitivity 88.24%, specificity 53.85%), fatigue (sensitivity 70.59%, specificity 76.92%).

CONCLUSIONS

EORTC QLQ-C30 questionnaire is a useful tool to early malnutrition diagnosis in head and neck cancer patients with short term results in nutritional condition, treatment response and a better QoL in this kind of patients.

摘要

引言

头颈癌治疗会限制经口摄入并导致营养不良。治疗期间充足的营养支持可减轻副作用的影响。

目的

描述欧洲癌症研究与治疗组织(EORTC)QLQ-C30量表在头颈癌患者营养不良风险筛查中的作用。

方法

对头颈癌患者进行分析性横断面诊断试验研究。我们通过Pearson和Spearman相关性分析,将营养不良诊断与主观全面评定法(SGA)以及EORTC QLQ-C30量表得分进行关联。我们绘制受试者工作特征(COR)曲线以计算EORTC QLQ-C30量表得分的切点;通过逻辑回归计算敏感性、特异性、阳性预测值、阴性预测值和比值比。

结果

功能量表(角色、身体、总体健康状况/生活质量)在头颈癌患者营养不良风险评估中的效用有限。具有强相关性的症状量表有:疼痛(敏感性76.47%,特异性69.23%)、失眠(敏感性88.24%,特异性53.85%)、疲劳(敏感性70.59%,特异性76.92%)。

结论

EORTC QLQ-C30问卷是早期诊断头颈癌患者营养不良的有用工具,对头颈癌患者的营养状况、治疗反应及生活质量有短期改善效果。

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