Eating Disorders Program, Douglas University Institute, Montreal, Quebec, Canada.
J Psychiatr Res. 2012 Sep;46(9):1139-45. doi: 10.1016/j.jpsychires.2012.05.018. Epub 2012 Jun 23.
We explored interaction effects involving polymorphisms of targeted dopamine system genes and selected forms of childhood abuse (sexual, physical and emotional) acting upon severity of binge-eating and psychopathological symptoms in women with Bulimia-Spectrum Disorders (BSDs).
Women diagnosed with a BSD (n = 216) were assessed for childhood traumata, eating-disorder (ED) symptoms, and selected psychopathological features (sensation seeking, impulsivity, compulsivity and affective instability), and then provided blood samples for genotyping of main polymorphisms of dopamine-2 receptor (DRD2), dopamine transporter (DAT1) and catechol o-methyltransferase (COMT) genes.
Sensation Seeking was elevated in carriers of the low-function allele of the DRD2 Taq1A polymorphism who also reported childhood sexual abuse, relative to that in individuals showing other combinations of alleles and abuse exposures. In addition, carriers of a low-function allele of COMT scored higher on compulsivity, lower on impulsivity, and marginally lower on frequency of binge-eating than did individuals in whom the allele was absent.
Our results suggest that genes acting within the dopamine system may contribute, either directly or indirectly (i.e., in interaction with traumatic childhood experiences), to variations in the presentation of comorbid traits and, possibly, of bulimic symptoms.
我们探讨了靶向多巴胺系统基因多态性与童年虐待（性虐待、身体虐待和情感虐待）特定形式之间的相互作用效应，这些因素会影响暴食症谱系障碍（BSD）女性的暴食和精神病理症状的严重程度。
对 216 名被诊断为 BSD 的女性进行了童年创伤、饮食障碍（ED）症状和特定精神病理特征（感觉寻求、冲动、强迫和情感不稳定）的评估，然后提供血液样本进行多巴胺-2 受体（DRD2）、多巴胺转运体（DAT1）和儿茶酚-O-甲基转移酶（COMT）基因主要多态性的基因分型。
与其他等位基因和虐待暴露组合的个体相比，携带 DRD2 Taq1A 多态性低功能等位基因且报告有童年性虐待的个体，感觉寻求度更高。此外，与不存在该等位基因的个体相比，COMT 低功能等位基因的携带者在强迫性方面得分更高，冲动性得分更低，暴食频率略低。
我们的结果表明，多巴胺系统内的基因可能通过直接或间接（即与创伤性童年经历相互作用）作用，导致共病特征和可能的暴食症状的表现存在差异。
