耐林可酰胺类 MLSB 基因 erm(43)在迟缓葡萄球菌中的发现。
New MLSB resistance gene erm(43) in Staphylococcus lentus.
机构信息
Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
出版信息
Antimicrob Agents Chemother. 2012 Sep;56(9):4746-52. doi: 10.1128/AAC.00627-12. Epub 2012 Jun 25.
Abstract
The search for a specific rRNA methylase motif led to the identification of the new macrolide, lincosamide, and streptogramin B resistance gene erm(43) in Staphylococcus lentus. An inducible resistance phenotype was demonstrated by cloning and expressing erm(43) and its regulatory region in Staphylococcus aureus. The erm(43) gene was detected in two different DNA fragments, of 6,230 bp and 1,559 bp, that were each integrated at the same location in the chromosome in several S. lentus isolates of human, dog, and chicken origin.
摘要
对特定 rRNA 甲基酶模体的研究导致了新型大环内酯类、林可酰胺类和链阳性菌素 B 耐药基因 erm(43)在葡萄球菌 lentus 中的发现。通过在金黄色葡萄球菌中克隆和表达 erm(43)及其调控区，证明了其具有诱导性耐药表型。在几个人源、犬源和鸡源的葡萄球菌 lentus 分离株中，erm(43)基因被检测到存在于两个不同的 DNA 片段中，分别为 6230bp 和 1559bp，它们都整合在染色体的相同位置上。
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