Tretli S, Haldorsen T
Cancer Registry of Norway, Montebello, Oslo.
J Epidemiol Community Health. 1990 Sep;44(3):215-9. doi: 10.1136/jech.44.3.215.
The aim was to study the influence of childbearing pattern on the incidence of breast cancer and uterine corpus cancer.
This was an ecological study of birth cohorts of women.
The study was population based, involving the whole of Norway.
The participants were Norwegian women born between 1890 and 1944.
Age specific fertility rates and age specific incidence rates for different birth cohorts were analysed by an age-cohort-period model where quantitative indices of the childbearing pattern substituted the cohort component. The 1890-94 birth cohort had the most favourable childbearing pattern with regard to the risk of breast cancer as well as uterine corpus cancer. The least favourable pattern was in the 1910-14 cohort for breast cancer and the 1940-44 cohort for uterine corpus cancer. In the analysis it is estimated that about 15% of the increase in incidence of breast cancer from 1955 to 1984 may be attributed to changes in the childbearing pattern of the cohorts under study. For cancer of the uterine corpus the corresponding fraction is about 27%.
The study reveals that changes in childbearing pattern may explain a certain fraction of the observed increase in breast and uterine corpus cancer in Norway in the last 30 years, but the largest fraction must be accounted for by other factors.
旨在研究生育模式对乳腺癌和子宫体癌发病率的影响。
这是一项针对女性出生队列的生态学研究。
该研究以人群为基础，涵盖整个挪威。
参与者为1890年至1944年出生的挪威女性。
通过年龄队列时期模型分析不同出生队列的年龄别生育率和年龄别发病率，其中生育模式的定量指标替代了队列成分。就乳腺癌和子宫体癌风险而言，1890 - 1894年出生队列的生育模式最为有利。对乳腺癌而言，最不利的模式出现在1910 - 1914年队列；对子宫体癌而言，最不利的模式出现在1940 - 1944年队列。分析估计，1955年至1984年乳腺癌发病率增加中约15%可能归因于所研究队列生育模式的变化。对于子宫体癌，相应比例约为27%。
该研究表明，生育模式的变化可能解释了挪威过去30年观察到的乳腺癌和子宫体癌增加的一定比例，但最大比例必须归因于其他因素。
