Nanomedicine (Lond). 2012 Jun;7(6):811-4. doi: 10.2217/nnm.12.54.
The 9th Conference and Workshop on Biological Barriers addressed relevant questions in the field of drug delivery based on nanoparticulate carrier systems. This includes the possibilities to overcome barriers such as the skin, the air-blood barrier in the lungs or the mucosa in the intestines. However, of utmost importance is the potential risk that may be associated with the intentional or unintentional exposure to these nanoparticulates, not only for medicinal use but also in a broader context. Hence, the conference spanned topics from clinical in vivo situations and the need for new technologies to the usage of in vitro model systems to understand the interaction of and allow for the screening of carriers and materials without the need for animal experiments.
第 9 届生物屏障会议和研讨会针对基于纳米载体系统的药物输送领域的相关问题进行了探讨。这包括克服皮肤、肺部的气-血屏障或肠道黏膜等屏障的可能性。然而，至关重要的是，与这些纳米颗粒的有意或无意暴露相关的潜在风险，不仅在医学用途方面，而且在更广泛的背景下也是如此。因此，会议涵盖了从临床体内情况和对新技术的需求到使用体外模型系统来理解载体和材料的相互作用并允许进行筛选，而无需进行动物实验等主题。
